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An exposure assessment of di-(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in human semen

Authors
 Sang Won Han  ;  Hyeyoung Lee  ;  Soon Young Han  ;  Duck Soo Lim  ;  Ki Kyung Jung  ;  Seung Jun Kwack  ;  Kyu Bong Kim  ;  Byung Mu Lee 
Citation
 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, Vol.72(21-22) : 1463-1469, 2009 
Journal Title
 JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES 
ISSN
 1528-7394 
Issue Date
2009
MeSH
Dibutyl Phthalate/analysis* ; Diethylhexyl Phthalate/analysis* ; Environmental Exposure* ; Environmental Pollutants/analysis ; Humans ; Male ; Plasticizers/analysis* ; Semen/chemistry* ; Young Adult
Abstract
Levels of the phthalates such as di(2-ethylhexyl) phthalate (DEHP), mono(2-ethylhexyl) phthalate (MEHP, a major metabolite of DEHP), di-n-butyl phthalate (DBP), mono-n-butyl phthalate (MBP, a major metabolite of DBP), and phthalic acid (P, (a common metabolite of phthalates, including DEHP and DBP) were determined in the semen samples of 99 healthy volunteers without known prior medicosurgical history. Samples were obtained from young men (age 20-25 yr) who visited a clinic, and the semen concentrations of phthalates were measured using ultra-performance liquid chromatography (UPLC) and tandem mass spectrometry (MS/MS). UPLC/MS/MS showed that mean concentrations in semen samples were 1.07 microg/ml for MEHP, 0.61 microg/ml for DEHP, 0.39 microg/ml for PA, 0.06 microg/ml for MBP, and 0.003 microg/ml for DBP. The concentration of MEHP (the metabolite of DEHP) was highest, and the concentrations of the metabolites including MEHP, MBP, and PA were higher than actual concentrations of parent DEHP and DBP. These findings suggest the detection of phthalates in healthy human semen might require further investigation for effects on human fertility.
Full Text
http://www.tandfonline.com/doi/abs/10.1080/15287390903212972
DOI
10.1080/15287390903212972
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105422
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