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Variability of response time as a predictor of methylphenidate treatment response in korean children with attention deficit hyperactivity disorder

 Seung-Hye Lee  ;  Dong-Ho Song  ;  Bung-Nyun Kim  ;  Yoo Sook Joung  ;  Eun Hye Ha  ;  Keun-Ah Cheon  ;  Yee-Jin Shin  ;  Hee Jeong Yoo  ;  Dong-Won Shin 
 YONSEI MEDICAL JOURNAL, Vol.50(5) : 650-655, 2009 
Journal Title
Issue Date
Adolescent ; Attention Deficit Disorder with Hyperactivity/drug therapy* ; Child ; Female ; Humans ; Korea ; Male ; Methylphenidate/therapeutic use* ; Reaction Time* ; Treatment Outcome
ADHD ; methylphenidate ; response time variability
PURPOSE: Methylphenidate (MPH) is an effective medication for the treatment of attention deficit hyperactivity disorder (ADHD). However, about 30% of patients do not respond to or are unable to tolerate MPH. Based on previous findings, we hypothesized that great variability in response time (RT) among Korean children with ADHD on a computerized continuous performance attention test would be related to poor MPH treatment response. MATERIALS AND METHODS: Children (ages 6-18 years) with ADHD were recruited for a prospective 12-week, open-labeled, multicenter study to examine optimal dosage of OROS methylphenidate. Of the 144 subjects selected, 28 dropped out due to adverse events, medication noncompliance, or follow-up loss, and an additional 26 subjects with comorbid disorders were excluded from statistical analyses. We defined 'responders' as subjects who received a score of less than 18 on the attention deficit hyperactivity disorder rating scale (ARS; Korean version, K-ARS) and a score of 1 or 2 on the Clinical Global Impression-Improvement scale (CGI-I). RT variability was assessed with the ADHD diagnostic system (ADS). RESULTS: Fifty-nine (67%) subjects responded to MPH treatment. The non-responders showed greater RT variability at baseline (Mann Whitney U = 577.0, p < 0.01). Baseline RT variability was a significant predictor of MPH response (Nagelkerke R(2) = 0.136, p < 0.01). It predicted 94.9% of responder, 17.2% of non-responder and 69.3% of overall group. CONCLUSION: High RT variability may predict poor response to MPH treatment in children with ADHD
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
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