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Optical detection of squamous cell carcinomas ex vivo for early diagnosis of cancerous oral tissues using combined spatial variance and ratio-based determinants

Authors
 Youngjin Oh  ;  Namkyeong Jeon  ;  Jin Kim  ;  Donghyun Kim 
Citation
 CURRENT APPLIED PHYSICS, Vol.9(4suppl.) : 206-209, 2009 
Journal Title
 CURRENT APPLIED PHYSICS 
ISSN
 1567-1739 
Issue Date
2009
Keywords
Optical diagnostics for medicine ; Spectroscopy ; Tissue diagnostics ; Dentistry
Abstract
We investigate optical signatures of normal and cancer tissues by measuring nine cases of oral squamous cell carcinomas transplanted into tongue of nude mice. Transmission results were measured with a spatially translated fiber probe for auto-fluorescence spectra of normal and cancer specimens in 450–750 nm. Normal and cancer specimens were quantitatively compared based on extinction coefficients (μt) calculated by collimated transmission method. Although direct comparison of μt may be difficult to detect cancer specimens, it was found that use of multiple determinants based on spatial variance and a spectral ratio of μt shows promise for the diagnosis. the preliminary results attest the feasibility and challenges of screening precancerous oral tissues using optical detection.
Full Text
http://www.sciencedirect.com/science/article/pii/S1567173909002788
DOI
10.1016/j.cap.2009.05.023
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Jeon, Nam kyeong(전남경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105380
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