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Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin

DC Field Value Language
dc.contributor.author박광균-
dc.contributor.author정원윤-
dc.date.accessioned2015-04-24T17:23:25Z-
dc.date.available2015-04-24T17:23:25Z-
dc.date.issued2009-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105310-
dc.description.abstractNovel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay-
dc.description.statementOfResponsibilityopen-
dc.format.extent6303~6306-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcetals/chemistry-
dc.subject.MESHAmides/chemical synthesis-
dc.subject.MESHAmides/chemistry*-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/drug effects-
dc.subject.MESHApoptosis/physiology-
dc.subject.MESHArtemisinins/chemical synthesis*-
dc.subject.MESHArtemisinins/chemistry-
dc.subject.MESHCell Proliferation-
dc.subject.MESHDrug Design-
dc.subject.MESHDrug Screening Assays, Antitumor/methods-
dc.subject.MESHEndothelium, Vascular/drug effects-
dc.subject.MESHEndothelium, Vascular/pathology-
dc.subject.MESHHumans-
dc.subject.MESHInhibitory Concentration 50-
dc.subject.MESHMice-
dc.subject.MESHMice, Nude-
dc.subject.MESHNeoplasm Transplantation-
dc.subject.MESHStructure-Activity Relationship-
dc.titleSynthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorMankil Jung-
dc.contributor.googleauthorNamsoo Park-
dc.contributor.googleauthorHyung-In Moon-
dc.contributor.googleauthorYongnam Lee-
dc.contributor.googleauthorWon-Yoon Chung-
dc.contributor.googleauthorKwang-Kyun Park-
dc.identifier.doi10.1016/j.bmcl.2009.09.093-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01429-
dc.contributor.localIdA03676-
dc.relation.journalcodeJ00326-
dc.identifier.eissn1464-3405-
dc.identifier.pmid19819696-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0960894X09013614-
dc.subject.keywordAnticancer activity-
dc.subject.keywordDeoxoartemisinin-
dc.subject.keywordNon-acetal type-
dc.subject.keywordAntiangiogenesis-
dc.contributor.alternativeNamePark, Kwang Kyun-
dc.contributor.alternativeNameChung, Won Yoon-
dc.contributor.affiliatedAuthorPark, Kwang Kyun-
dc.contributor.affiliatedAuthorChung, Won Yoon-
dc.citation.volume19-
dc.citation.number22-
dc.citation.startPage6303-
dc.citation.endPage6306-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.19(22) : 6303-6306, 2009-
dc.identifier.rimsid54691-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
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