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Effect of botulinum toxin type A injection into human masseter muscle on stimulated parotid saliva flow rate

Authors
 J.S.Kwon  ;  S.T.Kim  ;  Y.M.Jeon  ;  J.H.Choi 
Citation
 INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, Vol.38(4) : 316-320, 2009 
Journal Title
 INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 
ISSN
 0901-5027 
Issue Date
2009
MeSH
Adult ; Botulinum Toxins, Type A/administration & dosage ; Botulinum Toxins, Type A/adverse effects* ; Electromyography ; Female ; Follow-Up Studies ; Humans ; Hypertrophy/drug therapy ; Hypertrophy/physiopathology ; Injections, Intramuscular ; Male ; Masseter Muscle/drug effects ; Masseter Muscle/pathology* ; Masseter Muscle/physiopathology ; Neuromuscular Agents/administration & dosage ; Neuromuscular Agents/adverse effects* ; Parotid Gland/secretion* ; Saliva/secretion ; Salivation/drug effects* ; Secretory Rate ; Xerostomia/chemically induced* ; Young Adult
Keywords
botulinum toxin type A ; BTX-A ; masseter muscle ; stimulated parotid saliva
Abstract
Botulinum toxin type A (BTX-A) injection into the masseter muscles is used to treat masseteric hypertrophy. No serious side effects of BTX-A have been reported, but patients sometimes complain of xerostomia. The aim of this study was to evaluate the effect of injecting BTX-A into the masseter for the treatment of masseteric hypertrophy on the flow of saliva from the parotid gland. 34 volunteers enrolled in this study. A total of 25 units of BTX-A was injected into each side bilaterally at two points at the center of the lower third of the masseter muscle. Saliva was collected from the parotid gland over a period of 10 min to determine the flow rate for 18 weeks after injection. The flow rate was calculated by dividing the amount in milliliters by the collection time in minutes. There were no significant changes in the stimulated parotid saliva flow at 4, 8, 12 or 18 weeks compared with the baseline. Within this limited study, it can be concluded that BTX-A injection into the masseter does not cause any significant decrease in the production of saliva from the parotid gland.
Full Text
http://www.sciencedirect.com/science/article/pii/S0901502709000083
DOI
10.1016/j.ijom.2009.01.008
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jeong Seung(권정승) ORCID logo https://orcid.org/0000-0003-4584-7355
Kim, Seong Taek(김성택)
Jeon, Young Mi(전영미)
Choi, Jong Hoon(최종훈) ORCID logo https://orcid.org/0000-0003-3211-3619
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105280
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