아포크린 유방암의 임상병리적 특성

Abstract

Purpose: Apocrine carcinoma is a rare type of breast carcinoma, which has not been fully investigated. The aim of this study was to review clinicopathological features of apocrine carcinoma of the breast and to determine if there are some characteristics different from invasive ductal carcinoma. Methods: There were 4,064 breast cancer patients who had been managed in the Department of Surgery of Yonsei University College of Medicine from January 1997 to January 2008. Out of the patients, 16 patients with apocrine carcinoma and 2,997 patients with invasive ductal carcinoma were analyzed retrospectively. Results: The incidence of apocrine carcinoma was 0.4%. Most of the clinicopathologic features of apocrine carcinoma were similar to those of invasive ductal carcinoma. The percentage of estrogen receptor (ER) positivity and progesterone receptor (PR) positivity of apocrine carcinoma were all 12.5%. And the percentage of ER positivity and PR positivity of invasive ductal carcinoma were 64.2% and 55.2% respectively. Androgen receptor was only examined for eleven patients out of the 16 patients with apocrine carcinoma and the result were all positive. Conclusion: Apocrine carcinoma is also a rare disease in Korea. When compared with invasive ductal carcinoma, the disease did not appear to show any other significant difference in clinicopathologic characteristics but the percentages of ER and PR positivity of apocrine carcinoma seemed lower than those of invasive ductal carcinoma.