Cited 74 times in
Functional recovery after the transplantation of neurally differentiated mesenchymal stem cells derived from bone barrow in a rat model of spinal cord injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민유홍 | - |
dc.contributor.author | 박창일 | - |
dc.contributor.author | 신지철 | - |
dc.contributor.author | 이배환 | - |
dc.contributor.author | 임종백 | - |
dc.contributor.author | 조성래 | - |
dc.date.accessioned | 2015-04-24T17:20:25Z | - |
dc.date.available | 2015-04-24T17:20:25Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0963-6897 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105214 | - |
dc.description.abstract | This study was designed to investigate functional recovery after the transplantation of mesenchymal stem cells (MSCs) or neurally differentiated MSCs (NMSCs) derived from bone marrow in a rat model of spinal cord injury (SCI). Sprague-Dawley rats were subjected to incomplete SCI using an NYU impactor to create a free drop contusion at the T9 level. The SCI rats were then classified into three groups; MSCs, NMSCs, and phosphate-buffered saline (PBS)-treated groups. The cells or PBS were administrated 1 week after SCI. Basso-Beattie-Bresnahan (BBB) locomotor rating scores were measured at 1-week intervals for 9 weeks. Somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs) were also recorded 8 weeks after transplantation. While transplantation of MSCs led to a clear tendency of motor recovery, NMSC-treated rats had significantly improved BBB scores and showed significantly shortened initial latency, N1 latency, and P1 latency of the SSEPs compared to PBS controls. In addition, 5-bromo-2-deoxyuridine (BrdU)-prelabeled MSCs costained for BrdU and glial fibrillary acidic protein (GFAP) or myelin basic protein (MBP) were found rostrally and caudally 5 mm each from the epicenter of the necrotic cavity 4 weeks after transplantation. These results suggest that neurally differentiated cells might be an effective therapeutic source for functional recovery after SCI. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1359~1368 | - |
dc.relation.isPartOf | CELL TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Marrow Cells/cytology* | - |
dc.subject.MESH | Bromodeoxyuridine/metabolism | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glial Fibrillary Acidic Protein/metabolism | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Mesenchymal Stem Cell Transplantation* | - |
dc.subject.MESH | Mesenchymal Stromal Cells/cytology* | - |
dc.subject.MESH | Motor Activity | - |
dc.subject.MESH | Myelin Basic Protein/metabolism | - |
dc.subject.MESH | Nervous System/cytology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Recovery of Function | - |
dc.subject.MESH | Spinal Cord Injuries/therapy* | - |
dc.title | Functional recovery after the transplantation of neurally differentiated mesenchymal stem cells derived from bone barrow in a rat model of spinal cord injury | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Sung-Rae Cho | - |
dc.contributor.googleauthor | Yong Rae Kim | - |
dc.contributor.googleauthor | Hoi-Sung Kang | - |
dc.contributor.googleauthor | Sun Hee Yim | - |
dc.contributor.googleauthor | Chang-il Park | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.contributor.googleauthor | Bae Hwan Lee | - |
dc.contributor.googleauthor | Ji Cheol Shin | - |
dc.contributor.googleauthor | Jong-Baeck Lim | - |
dc.identifier.doi | 10.3727/096368909X475329 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A01717 | - |
dc.contributor.localId | A02162 | - |
dc.contributor.localId | A02791 | - |
dc.contributor.localId | A03403 | - |
dc.contributor.localId | A03831 | - |
dc.relation.journalcode | J00492 | - |
dc.identifier.eissn | 1555-3892 | - |
dc.identifier.pmid | 20184788 | - |
dc.identifier.url | http://www.ingentaconnect.com/content/cog/ct/2009/00000018/00000012/art00008 | - |
dc.subject.keyword | Spinal cord injury | - |
dc.subject.keyword | Transplantation | - |
dc.subject.keyword | Mesenchymal stem cells | - |
dc.subject.keyword | Neural differentiation | - |
dc.subject.keyword | Functional recovery | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.alternativeName | Park, Chang Il | - |
dc.contributor.alternativeName | Shin, Ji Cheol | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.contributor.alternativeName | Lim, Jong Baeck | - |
dc.contributor.alternativeName | Cho, Sung Rae | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Park, Chang Il | - |
dc.contributor.affiliatedAuthor | Shin, Ji Cheol | - |
dc.contributor.affiliatedAuthor | Lee, Bae Hwan | - |
dc.contributor.affiliatedAuthor | Lim, Jong Baeck | - |
dc.contributor.affiliatedAuthor | Cho, Sung Rae | - |
dc.citation.volume | 18 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1359 | - |
dc.citation.endPage | 1368 | - |
dc.identifier.bibliographicCitation | CELL TRANSPLANTATION, Vol.18(12) : 1359-1368, 2009 | - |
dc.identifier.rimsid | 53197 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.