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Relationship of low-density lipoprotein (LDL) particle size to thyroid function status in Koreans

 Chul Sik Kim  ;  Jun Goo Kang  ;  Seong Jin Lee  ;  Sung Hee Ihm  ;  Hyung Joon Yoo  ;  Ji Sun Nam  ;  Chul Woo Ahn  ;  Kyung Rae Kim 
 CLINICAL ENDOCRINOLOGY, Vol.71(1) : 130-136, 2009 
Journal Title
Issue Date
Adult ; Aged ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Humans ; Hypothyroidism/blood* ; Hypothyroidism/complications ; Hypothyroidism/physiopathology ; Lipoproteins, LDL/blood ; Lipoproteins, LDL/chemistry* ; Male ; Middle Aged ; Particle Size ; Risk Factors ; Thyroid Function Tests ; Thyroid Gland/physiopathology*
OBJECTIVE: Dyslipidaemia is a well-known manifestation of thyroid dysfunction. Recently, small low-density lipoprotein (LDL) particle size has been linked with development of cardiovascular disease. To better understand the effects of thyroid dysfunction on the development of cardiovascular disease, we examined LDL particle size and lipid profiles in subjects with different thyroid function. METHODS: Included were 46 patients with overt hypothyroidism, 57 patients with subclinical hypothyroidism, 46 patients with overt hyperthyroidism, 51 patients with subclinical hyperthyroidism, and 110 age- and sex-matched healthy control subjects. We measured LDL particle size and lipid profiles in these subjects. RESULTS: No significant differences were found in LDL particle size between the groups with different thyroid function. Serum total cholesterol and LDL-cholesterol levels were significantly higher in the cases of hypothyroidism than in the cases of hyperthyroidism and the healthy control subjects. Serum triglyceride levels were higher in subjects with overt hypothyroidism than in those with overt hyperthyroidism or healthy control subjects. CONCLUSIONS: LDL particle size, the emerging risk factor for atherosclerosis, did not appear to be significantly affected by the degree of thyroid dysfunction. Increased risk of atherosclerosis in hypothyroidism does not appear to be associated with LDL particle size, the non-traditional cardiovascular risk factor.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
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