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Posterior reversible encephalopathy syndrome in childhood with hematologic/oncologic diseases

Authors
 Sung Chul Won  ;  Seung Yeon Kwon  ;  Jung Woo Han  ;  Seong Yeol Choi  ;  Chuhl Joo Lyu 
Citation
 JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, Vol.31(7) : 505-508, 2009 
Journal Title
 JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 
ISSN
 1077-4114 
Issue Date
2009
MeSH
Adolescent ; Brain Diseases/etiology* ; Brain Diseases/pathology* ; Child ; Child, Preschool ; Female ; Hematologic Diseases/complications* ; Hematologic Diseases/therapy ; Humans ; Immunosuppressive Agents/adverse effects ; Magnetic Resonance Imaging ; Male ; Neoplasms/complications* ; Neoplasms/therapy ; Seizures/etiology ; Stem Cell Transplantation/adverse effects ; Syndrome
Keywords
child ; cancer ; chemotherapy ; hypertension ; encephalopathy
Abstract
Posterior reversible encephalopathy syndrome (PRES) is a clinico-neuroradiologic disease entity represented by characteristic magnetic resonance image (MRI) findings of subcortical/cortical hyperintensity in T2-weighted sequences, more often observed in parieto-occipital lobes, accompanied by clinical neurologic alterations. PRES is a rare central nervous system complication in childhood hematologic-oncologic patients and shows very different neurologic symptoms between patients, from numbness on extremities to generalized seizure. The etiology of PRES was not well known until these days. In this study, 8 patients with PRES were reviewed, retrospectively. There were 4 patients with acute lymphocytic leukemia, 1 with aplastic anemia, and 3 with solid tumors (1 patient each for neuroblastoma, Ewing sarcoma, and osteosarcoma). Allogeneic stem cell transplantation was performed in 2 patients. Immunosuppressive agents such as tacrolimus and cyclosporine A were used in 3 patients. One neuroblastoma patient was in immediate postoperative status. All patients experienced seizure attacks of different types and showed typical MRI findings. Follow-up MRIs revealed significant improvements. From this review, we might consider chemotherapy and surgery as additive causes for PRES other than immunosuppressive agents. Therefore, careful examination of the patients receiving chemotherapy and surgery was needed to find out this uncommon but good prognostic complication.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00043426-200907000-00009&LSLINK=80&D=ovft
DOI
10.1097/MPH.0b013e3181a71868
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Seung Yeon(권승연)
Won, Sung Chul(원성철)
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105200
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