Cited 1 times in
Microplate hybridization assay for detection of isoniazid resistance in Mycobacterium tuberculosis
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2015-04-24T17:17:50Z | - |
dc.date.available | 2015-04-24T17:17:50Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105130 | - |
dc.description.abstract | Early and accurate detection of drug resistant Mycobacterium tuberculosis can improve both the treatment outcome and public health control of tuberculosis. A number of molecular-based techniques have been developed including ones using probe molecules that target drug resistance-related mutations. Although these techniques are highly specific and sensitive, mixed signals can be obtained when the drug resistant isolates are mixed with drug susceptible isolates. In order to overcome this problem, we developed a new drug susceptibility test (DST) for one of the most effective anti-tuberculosis drug, isoniazid. This technique employed a microplate hybridization assay that quantified signals from each probe molecule, and was evaluated using clinical isolates. The evaluation analysis clearly showed that the microplate hybridization assay was an accurate and rapid method that overcame the limitations of DST based on conventional molecular techniques. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 81~85 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antitubercular Agents/pharmacology* | - |
dc.subject.MESH | Antitubercular Agents/therapeutic use | - |
dc.subject.MESH | Biological Assay/instrumentation | - |
dc.subject.MESH | Biological Assay/methods* | - |
dc.subject.MESH | Drug Resistance, Bacterial* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Isoniazid/pharmacology* | - |
dc.subject.MESH | Isoniazid/therapeutic use | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Mycobacterium tuberculosis/drug effects* | - |
dc.subject.MESH | Mycobacterium tuberculosis/physiology | - |
dc.subject.MESH | Nucleic Acid Hybridization | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/drug therapy | - |
dc.subject.MESH | Tuberculosis, Multidrug-Resistant/microbiology | - |
dc.title | Microplate hybridization assay for detection of isoniazid resistance in Mycobacterium tuberculosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Hye Eun Han | - |
dc.contributor.googleauthor | In Soo Lee | - |
dc.contributor.googleauthor | Joo Hwan Hwang | - |
dc.contributor.googleauthor | Hye Eun Bang | - |
dc.contributor.googleauthor | Yeun Kim | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Tae Ue Kim | - |
dc.contributor.googleauthor | Hye Young Lee | - |
dc.identifier.doi | 10.5483/BMBRep.2009.42.2.081 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J00348 | - |
dc.identifier.eissn | 1976-670X | - |
dc.identifier.pmid | 19250607 | - |
dc.subject.keyword | Isoniazid (INH) | - |
dc.subject.keyword | MDR-TB | - |
dc.subject.keyword | Microplate hybridization assay | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.citation.volume | 42 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 81 | - |
dc.citation.endPage | 85 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, Vol.42(2) : 81-85, 2009 | - |
dc.identifier.rimsid | 56773 | - |
dc.type.rims | ART | - |
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