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Blood pressure is a major risk factor for renal death: an analysis of 560 352 participants from the Asia-Pacific region.

Authors
 Conall M. O’Seaghdha  ;  Vlado Perkovic  ;  Tai Hing Lam  ;  Stella McGinn  ;  Federica Barzi  ;  Dong Feng Gu  ;  Alan Cass  ;  Il Suh  ;  Paul Muntner  ;  Graham G. Giles  ;  Hirotsugu Ueshima  ;  Mark Woodward  ;  Rachel Huxley 
Citation
 HYPERTENSION, Vol.54(3) : 509-515, 2009 
Journal Title
 HYPERTENSION 
ISSN
 0194-911X 
Issue Date
2009
MeSH
Adult ; Aged ; Asia ; Australia ; Blood Glucose/analysis ; Blood Pressure/physiology* ; Cause of Death ; Cholesterol/blood ; Cholesterol, HDL/blood ; Cohort Studies ; Diabetes Mellitus/blood ; Diabetes Mellitus/physiopathology ; Fasting/blood ; Female ; Follow-Up Studies ; Humans ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/mortality* ; Kidney Failure, Chronic/physiopathology* ; Male ; Middle Aged ; Outcome Assessment (Health Care)/statistics & numerical data ; Proportional Hazards Models ; Risk Factors ; Survival Rate
Keywords
risk factors ; renal mortality ; hypertension ; diabetes mellitus ; impaired fasting glucose
Abstract
Chronic kidney disease is a major worldwide public health problem that causes substantial morbidity and mortality. Studies from the Asia-Pacific region have reported some of the highest chronic kidney disease prevalence rates in the world, but access to dialysis is limited in many countries, making it imperative to identify high-risk individuals. We performed a participant-level data overview of prospective studies conducted in the Asia-Pacific region to quantify the magnitude and direction of the associations between putative risk factors and renal death. Age- and sex-adjusted Cox proportional hazards models were applied to pooled data from 35 studies to calculate hazard ratios (95% CIs) for renal death associated with a standardized change in risk factors. Among 560 352 participants followed for a median of 6.8 years, a total of 420 renal deaths were observed. Continuous and positive associations among systolic blood pressure, diastolic blood pressure, fasting blood glucose, and total cholesterol levels with renal death were observed, as well as a continuous but inverse association with high-density lipoprotein cholesterol. Systolic blood pressure was the strongest risk factor for renal death with each SD increase in systolic blood pressure (19 mm Hg) associated with >80% higher risk (hazard ratio: 1.84; 95% CI: 1.60 to 2.12). Neither cigarette smoking nor excess weight was related to the risk of renal death (P>0.10). The results were similar for cohorts in Asia and Australia. These results suggest that primary prevention strategies for renal disease should focus on individuals with elevated blood pressure, diabetes mellitus, and dyslipidemia.
Files in This Item:
T200903483.pdf Download
DOI
10.1161/HYPERTENSIONAHA.108.128413
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105081
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