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환자-대조군 연구에서 인구집단 층화가 일배체형 경향성 검정에 미치는 영향

Other Titles
 Study on Effects of Population Stratification on Haplotype Trend Test in Case-Control Studies 
Authors
 김진흠  ;  강대룡  ;  임현선  ;  남정모 
Citation
 Korean Journal of Applied Statistics (응용통계연구), Vol.22(5) : 1085-1096, 2009 
Journal Title
Korean Journal of Applied Statistics(응용통계연구)
ISSN
 1225-066X 
Issue Date
2009
Keywords
Population stratification ; spurious association ; false positive ; haplotype trend test ; measurement error
Abstract
Population stratification can cause spurious associations between genetic markers and disease locus. In order to handle this population stratification in haplotype-based case-control association studies, we added population indicators as covariates to the haplotype trend regression model proposed by Zaykin et al. (2002). We investigated through simulations how both population stratification and measurement error in the estimation of true population of each individual affect type I error probabilities of the association tests based on both Zaykin et al.'s (2002) model and the proposed model. Based on those results, in the situation that there exists population stratification but there is no error in population classification of each individual, our proposed model does satisfy a type I error probability whereas Zaykin et al.'s (2002) model does not. However, as the measurement error increases, a type I error probability of our model correspondingly becomes larger than a nominal significance level. It implies that as long as uncertainty in the estimation of true population of each individual still remains, it is nearly impossible to avoid false positive in case-control association studies based on haplotypes
Files in This Item:
T200903477.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kang, Dae Ryong(강대용)
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105072
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