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Soy food consumption and risk of prostate cancer: a meta-analysis of observational studies

Authors
 YeWon Hwang  ;  Soo Young Kim  ;  Sun Ha Jee  ;  Youn Nam Kim  ;  Chung Mo Nam 
Citation
 NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, Vol.61(5) : 598-606, 2009 
Journal Title
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
ISSN
 0163-5581 
Issue Date
2009
MeSH
Anticarcinogenic Agents/administration & dosage* ; Genistein/administration & dosage ; Humans ; Isoflavones/administration & dosage ; Male ; Odds Ratio ; Prostatic Neoplasms/epidemiology* ; Risk Factors ; Soy Foods*/analysis
Abstract
Soybean products have been suggested to have a chemo preventive effect against prostate cancer. The aim of this study was to provide a comprehensive meta-analysis on the extent of the possible association between soy-based food consumption and the risk of prostate cancer. Five cohort studies and 8 case-control studies were identified using MEDLINE, EMBASE, CINAHL, Korea Medical Database, KoreaMed, Korean studies Information Service System, Japana Centra Revuo Medicina, China National Knowledge Infrastructure, and a manual search. Summary odds ratios (ORs) comparing high versus low categories of soybean consumptions were calculated on the basis of the random effect model. We analyzed the associations based on the different types of soybean consumptions. The summary ORs (95% CI) for total soy foods were 0.69 (CI = 0.57-0.84) and 0.75 (CI = 0.62-0.89) for nonfermented soy foods. Among individual soy foods, only tofu yielded a significant value of 0.73 (CI = 0.57-0.92). Consumption of soybean milk, miso, or natto did not significantly reduce the risk of prostate cancer. Genistein and daidzein were associated with a lower risk of prostate cancer. This systematic review suggests that soy food consumption could lower the risk of prostate cancer. This conclusion, however, should be interpreted with caution because various biases can affect the results of a meta-analysis.
Full Text
http://www.tandfonline.com/doi/abs/10.1080/01635580902825639
DOI
10.1080/01635580902825639
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105066
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