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Allergenicity of sigma and delta class glutathione S-transferases from the German cockroach.

DC FieldValueLanguage
dc.contributor.author용태순-
dc.contributor.author이명희-
dc.contributor.author이한일-
dc.contributor.author정경용-
dc.contributor.author홍천수-
dc.date.accessioned2015-04-24T17:15:00Z-
dc.date.available2015-04-24T17:15:00Z-
dc.date.issued2009-
dc.identifier.issn1018-2438-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/105038-
dc.description.abstractBACKGROUND: Cockroach glutathione S-transferases (GSTs) are known to elicit strong IgE responses. This study was undertaken to compare the IgE reactivity of German cockroach GSTs, Bla g 5 (sigma class) and delta class GST (BgGSTD1). METHODS: Full-length Bla g 5 and BgGSTD1 were cloned, and their recombinant proteins were expressed and purified. Their IgE reactivities and cross-reactivities were examined by ELISA using sera from cockroach-sensitized subjects. RESULTS: A predominant variant of Bla g 5 cDNA has amino acid substitutions at positions 10 (C to F) and 42 (N to K). BgGSTD1 has substitutions at positions 27 (E to N) and 207 (K to R). Sera from cockroach-sensitized patients showed 20.5% IgE reactivity to Bla g 5 and 17.9% IgE reactivity to BgGSTD1. However, inhibition studies using 1 serum sample with the highest IgE reactivity showed limited cross-reactivity. CONCLUSIONS: IgE-binding frequency to the cockroach GSTs was low, but the titer of IgE reactivity was strong in some sera. The inclusion of different classes of GSTs could be helpful for the delicate diagnosis and immunotherapy of cockroach allergy-
dc.description.statementOfResponsibilityopen-
dc.format.extent59~64-
dc.relation.isPartOfInternational Archives of Allergy and Immunology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAllergenicity of sigma and delta class glutathione S-transferases from the German cockroach.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKyoung Yong Jeong-
dc.contributor.googleauthorKyoung-jin Jeong-
dc.contributor.googleauthorMyung-hee Yi-
dc.contributor.googleauthorHaeseok Lee-
dc.contributor.googleauthorChein-Soo Hong-
dc.contributor.googleauthorTai-Soon Yong-
dc.identifier.doi10.1159/000151506-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02424-
dc.contributor.localIdA02761-
dc.contributor.localIdA03279-
dc.contributor.localIdA03572-
dc.contributor.localIdA04448-1-
dc.relation.journalcodeJ01074-
dc.identifier.urlhttp://www.karger.com/Article/FullText/151506-
dc.contributor.alternativeNameYong, Tai Soon-
dc.contributor.alternativeNameYi, Myung Hee-
dc.contributor.alternativeNameRee, Han Il-
dc.contributor.alternativeNameJeong, Kyoung Yong-
dc.contributor.alternativeNameHong, Chein Soo-
dc.contributor.affiliatedAuthorYong, Tai Soon-
dc.contributor.affiliatedAuthorYi, Myung Hee-
dc.contributor.affiliatedAuthorRee, Han Il-
dc.contributor.affiliatedAuthorJeong, Kyoung Yong-
dc.contributor.affiliatedAuthorHong, Chein Soo-
dc.citation.volume148-
dc.citation.number1-
dc.citation.startPage59-
dc.citation.endPage64-
dc.identifier.bibliographicCitationInternational Archives of Allergy and Immunology, Vol.148(1) : 59-64, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Allergy (알레르기연구소) > 1. Journal Papers

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