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Hyperhomocysteinemia in patients with parkinson's disease and relationship to vitamin B level

Authors
 Hae-Won Shin  ;  Young Ho Sohn 
Citation
 JOURNAL OF MOVEMENT DISORDERS, Vol.2 : 33-36, 2009 
Journal Title
JOURNAL OF MOVEMENT DISORDERS
ISSN
 2093-4939 
Issue Date
2009
Keywords
Homocysteine ; Parkinson’s disease ; Vitamin B
Abstract
Background: Plasma homocysteine (Hcy) levels are increased in patients with Parkinson’s
disease (PD) undergoing levodopa treatment. We measured the Hcy levels in PD patients
and assessed the relationship between Hcy level and features of PD, cognitive function and
vitamin B status. Methods: Concentrations of Hcy, vitamin B12 and folate were measured
in 33 PD patients and 41 normal control individuals. Mini-mental Status Examination
(MMSE) was assessed in all subjects. In PD patients, Hoehn & Yahr stage and Unified
Parkinson Disease Rating Scale (UPDRS) motor scores were also examined. Results:
Plasma Hcy levels were lower in PD patients than in control individuals. Hcy level was
inversely correlated with vitamin B12 and folate levels in the PD group but not in control
individuals. Age, symptom duration, UPDRS motor scores, MMSE score, levodopa dose
and duration of treatment did not differ between patients with Hcy >14 μmol/L and those
with Hcy <14 μmol/L. Conclusions: Plasma Hcy levels were increased in PD patients
with levodopa treatment and were related to vitamin B level. These results indicate that
vitamin supplementation may be beneficial in levodopa-treated PD patients, although hyperhomocysteinemia
did not affect the motor and cognitive status of PD patients
Files in This Item:
T200903415.pdf Download
DOI
10.14802/jmd.09008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105011
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