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Correlation of human leukocyte antigen-G (HLA-G) expression and disease progression in epithelial ovarian cancer

Authors
 Yong Wook Jung  ;  Young Tae Kim  ;  Sang Wun Kim  ;  Sunghoon Kim  ;  Jae Hoon Kim  ;  Nam Hoon Cho  ;  Jae Wook Kim 
Citation
 REPRODUCTIVE SCIENCES, Vol.16(11) : 1103-1111, 2009 
Journal Title
 REPRODUCTIVE SCIENCES 
ISSN
 1933-7191 
Issue Date
2009
MeSH
Adolescent ; Adult ; Aged ; Biomarkers, Tumor/metabolism ; Blotting, Western ; Carcinoma/metabolism* ; Carcinoma/pathology ; Disease Progression ; Female ; Flow Cytometry ; HLA Antigens/metabolism* ; HLA-G Antigens ; Histocompatibility Antigens Class I/metabolism* ; Humans ; Immunohistochemistry ; Middle Aged ; Neoplasm Staging ; Ovarian Neoplasms/metabolism* ; Ovarian Neoplasms/pathology ; Ovary/metabolism* ; Ovary/pathology ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Statistics, Nonparametric
Keywords
Human leukocyte antigen-G ; ovarian cancer ; prognosis
Abstract
Human leukocyte antigen-G (HLA-G) expression has been reported to be relevant to cancer development and immune tolerance. The purpose of this study was to investigate the correlation between HLA-G expression and disease progression and to assess the use of HLA-G expression as a prognostic immunomarker in epithelial ovarian carcinoma. Human leukocyte antigen-G expression in 41 ovarian cancer tissues and 8 normal ovarian tissues was analyzed using immunohistochemistry and Western blot assay. Quantitative real-time reverse transcription polymerase chain reaction (RT-PCR) was used for HLA-G messenger RNA (mRNA) expression. Human leukocyte antigen-G mRNA and protein levels were significantly greater in advanced ovarian cancer tissues than in normal or early stage ovarian cancer tissues (P < .05 and P < .05, respectively). Patients with HLA-G expression had a significantly worse prognosis. There is a significant correlation between HLA-G immunoreactivity and patient survival in univariate analysis (P = .04). Our data was consistent with the concept that HLA-G expression might play a pivotal role in the development and disease progression of epithelial ovarian cancer.
Full Text
http://rsx.sagepub.com/content/16/11/1103
DOI
10.1177/1933719109342131
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Wook(김재욱)
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Jung, Yong Wook(정용욱)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104940
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