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Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma

DC FieldValueLanguage
dc.contributor.author김주영-
dc.contributor.author박중원-
dc.contributor.author손정호-
dc.date.accessioned2015-04-24T17:11:15Z-
dc.date.available2015-04-24T17:11:15Z-
dc.date.issued2009-
dc.identifier.issn0091-6749-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104920-
dc.description.abstractBACKGROUND: A T(H)1-specific transcription factor, T-box-containing protein expressed in T cells (T-bet), controls the production of both T(H)1 and T(H)2 cytokines in T(H) cell differentiation by means of distinct mechanisms. T-bet-deficient mice overproduce T(H)2 cytokines and have spontaneous airway inflammation. OBJECTIVES: We tested whether T-bet overexpression could protect against the development or progression of asthma. METHODS: We generated a T cell-specific and inducible line of T-bet-transgenic mice on a T-bet-deficient genetic background and used it to study the function of T-bet in an ovalbumin (OVA)-induced asthma model. RESULTS: Induction of T-bet in a T cell-specific manner in an OVA model of asthma concomitant with OVA injection prevented airway hyperresponsiveness, eosinophilic and lymphocytic inflammation, and IL-5 and IL-13 production in bronchoalveolar lavage fluid and also reduced serum IgE and T(H)2 cytokine production by peripheral T cells. Even when T-bet expression was induced during later stages of asthma progression, T-bet overexpression still attenuated airway hyperresponsiveness and goblet cell hyperplasia, as well as T(H)2 cytokine production. CONCLUSIONS: Our results suggest that T-bet expression in T cells can prevent the initiation of airway inflammation and progression of chronic inflammation and might be extrapolated to human asthma.-
dc.description.statementOfResponsibilityopen-
dc.format.extent479~485-
dc.relation.isPartOfJournal of Allergy and Clinical Immunology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAllergens/immunology-
dc.subject.MESHAnimals-
dc.subject.MESHAsthma/immunology*-
dc.subject.MESHAsthma/metabolism-
dc.subject.MESHBronchoalveolar Lavage Fluid/chemistry-
dc.subject.MESHBronchoalveolar Lavage Fluid/immunology-
dc.subject.MESHCytokines/drug effects-
dc.subject.MESHCytokines/immunology*-
dc.subject.MESHCytokines/metabolism-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHDoxycycline/pharmacology-
dc.subject.MESHEosinophilia/immunology-
dc.subject.MESHEosinophilia/metabolism-
dc.subject.MESHGoblet Cells/immunology-
dc.subject.MESHGoblet Cells/pathology-
dc.subject.MESHImmunoglobulin E/blood-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMice, Transgenic-
dc.subject.MESHOvalbumin/immunology-
dc.subject.MESHT-Box Domain Proteins/genetics-
dc.subject.MESHT-Box Domain Proteins/metabolism*-
dc.subject.MESHT-Lymphocytes/drug effects-
dc.subject.MESHT-Lymphocytes/immunology*-
dc.subject.MESHT-Lymphocytes/metabolism-
dc.subject.MESHTh2 Cells/drug effects-
dc.subject.MESHTh2 Cells/immunology*-
dc.subject.MESHTh2 Cells/metabolism-
dc.titleRestoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJung Won Park-
dc.contributor.googleauthorHyun Jung Min-
dc.contributor.googleauthorJung Ho Sohn-
dc.contributor.googleauthorJoo Young Kim-
dc.contributor.googleauthorJeong Ho Hong-
dc.contributor.googleauthorKirsten S. Sigrist-
dc.contributor.googleauthorLaurie H. Glimcher-
dc.contributor.googleauthorEun Sook Hwang-
dc.identifier.doi10.1016/j.jaci.2008.10.035-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01681-
dc.contributor.localIdA01993-
dc.contributor.localIdA00938-
dc.relation.journalcodeJ01228-
dc.identifier.pmid19081613-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0091674908018897-
dc.subject.keywordT-bet-
dc.subject.keywordT cell-
dc.subject.keywordtransgenic mice-
dc.subject.keywordOVA-
dc.subject.keywordasthma-
dc.subject.keywordairway hyperresponsiveness-
dc.contributor.alternativeNameKim, Joo Young-
dc.contributor.alternativeNamePark, Jung Won-
dc.contributor.alternativeNameSohn, Jung Ho-
dc.contributor.affiliatedAuthorPark, Jung Won-
dc.contributor.affiliatedAuthorSohn, Jung Ho-
dc.contributor.affiliatedAuthorKim, Joo Young-
dc.citation.volume123-
dc.citation.number2-
dc.citation.startPage479-
dc.citation.endPage485-
dc.identifier.bibliographicCitationJournal of Allergy and Clinical Immunology, Vol.123(2) : 479-485, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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