Cited 19 times in
Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma
DC Field | Value | Language |
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dc.contributor.author | 김주영 | - |
dc.contributor.author | 박중원 | - |
dc.contributor.author | 손정호 | - |
dc.date.accessioned | 2015-04-24T17:11:15Z | - |
dc.date.available | 2015-04-24T17:11:15Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104920 | - |
dc.description.abstract | BACKGROUND: A T(H)1-specific transcription factor, T-box-containing protein expressed in T cells (T-bet), controls the production of both T(H)1 and T(H)2 cytokines in T(H) cell differentiation by means of distinct mechanisms. T-bet-deficient mice overproduce T(H)2 cytokines and have spontaneous airway inflammation. OBJECTIVES: We tested whether T-bet overexpression could protect against the development or progression of asthma. METHODS: We generated a T cell-specific and inducible line of T-bet-transgenic mice on a T-bet-deficient genetic background and used it to study the function of T-bet in an ovalbumin (OVA)-induced asthma model. RESULTS: Induction of T-bet in a T cell-specific manner in an OVA model of asthma concomitant with OVA injection prevented airway hyperresponsiveness, eosinophilic and lymphocytic inflammation, and IL-5 and IL-13 production in bronchoalveolar lavage fluid and also reduced serum IgE and T(H)2 cytokine production by peripheral T cells. Even when T-bet expression was induced during later stages of asthma progression, T-bet overexpression still attenuated airway hyperresponsiveness and goblet cell hyperplasia, as well as T(H)2 cytokine production. CONCLUSIONS: Our results suggest that T-bet expression in T cells can prevent the initiation of airway inflammation and progression of chronic inflammation and might be extrapolated to human asthma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 479~485 | - |
dc.relation.isPartOf | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Allergens/immunology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Asthma/immunology* | - |
dc.subject.MESH | Asthma/metabolism | - |
dc.subject.MESH | Bronchoalveolar Lavage Fluid/chemistry | - |
dc.subject.MESH | Bronchoalveolar Lavage Fluid/immunology | - |
dc.subject.MESH | Cytokines/drug effects | - |
dc.subject.MESH | Cytokines/immunology* | - |
dc.subject.MESH | Cytokines/metabolism | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Doxycycline/pharmacology | - |
dc.subject.MESH | Eosinophilia/immunology | - |
dc.subject.MESH | Eosinophilia/metabolism | - |
dc.subject.MESH | Goblet Cells/immunology | - |
dc.subject.MESH | Goblet Cells/pathology | - |
dc.subject.MESH | Immunoglobulin E/blood | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | Ovalbumin/immunology | - |
dc.subject.MESH | T-Box Domain Proteins/genetics | - |
dc.subject.MESH | T-Box Domain Proteins/metabolism* | - |
dc.subject.MESH | T-Lymphocytes/drug effects | - |
dc.subject.MESH | T-Lymphocytes/immunology* | - |
dc.subject.MESH | T-Lymphocytes/metabolism | - |
dc.subject.MESH | Th2 Cells/drug effects | - |
dc.subject.MESH | Th2 Cells/immunology* | - |
dc.subject.MESH | Th2 Cells/metabolism | - |
dc.title | Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jung Won Park | - |
dc.contributor.googleauthor | Hyun Jung Min | - |
dc.contributor.googleauthor | Jung Ho Sohn | - |
dc.contributor.googleauthor | Joo Young Kim | - |
dc.contributor.googleauthor | Jeong Ho Hong | - |
dc.contributor.googleauthor | Kirsten S. Sigrist | - |
dc.contributor.googleauthor | Laurie H. Glimcher | - |
dc.contributor.googleauthor | Eun Sook Hwang | - |
dc.identifier.doi | 10.1016/j.jaci.2008.10.035 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01681 | - |
dc.contributor.localId | A01993 | - |
dc.contributor.localId | A00938 | - |
dc.relation.journalcode | J01228 | - |
dc.identifier.eissn | 1097-6825 | - |
dc.identifier.pmid | 19081613 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0091674908018897 | - |
dc.subject.keyword | T-bet | - |
dc.subject.keyword | T cell | - |
dc.subject.keyword | transgenic mice | - |
dc.subject.keyword | OVA | - |
dc.subject.keyword | asthma | - |
dc.subject.keyword | airway hyperresponsiveness | - |
dc.contributor.alternativeName | Kim, Joo Young | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.alternativeName | Sohn, Jung Ho | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Sohn, Jung Ho | - |
dc.contributor.affiliatedAuthor | Kim, Joo Young | - |
dc.citation.volume | 123 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 479 | - |
dc.citation.endPage | 485 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol.123(2) : 479-485, 2009 | - |
dc.identifier.rimsid | 42576 | - |
dc.type.rims | ART | - |
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