Acute myocardial infarction due to vasospasm induced by prostaglandin

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Authors: Chong Won Sung ; Jae-Hun Jung ; Sang-Hak Lee ; Kyung Min Lee ; Byung Moo Ahn ; Seonghoon Choi ; Jung Rae Cho ; Namho Lee ; Keun-Young Lee

MeSH: Administration, Intravaginal ; Adult ; Alprostadil/administration & dosage ; Alprostadil/adverse effects* ; Coronary Angiography ; Coronary Vasospasm/chemically induced* ; Coronary Vasospasm/complications ; Coronary Vasospasm/diagnosis ; Electrocardiography ; Female ; Humans ; Myocardial Infarction/diagnosis ; Myocardial Infarction/etiology* ; Myocardial Infarction/physiopathology ; Pregnancy ; Pregnancy Complications, Cardiovascular* ; Pregnancy Outcome ; Vasodilator Agents/administration & dosage ; Vasodilator Agents/adverse effects

Abstract: Prostaglandin E (PGE) is the preferred agent for second-trimester pregnancy termination. Hypotension, bradycardia, ventricular arrhythmias, myocardial infarction, cardiac arrest and death associated with PGE have been reported. A case of acute myocardial infarction due to coronary vasospasm induced by PGE is described in the present report. The diagnosis was confirmed by electrocardiography and coronary angiography