Cited 9 times in
Increments of alpha-dystroglycan expression in liver metastasis correlate with poor survival in gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 문용화 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 유내춘 | - |
dc.contributor.author | 정재헌 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.contributor.author | 권오빈 | - |
dc.contributor.author | 라선영 | - |
dc.date.accessioned | 2015-04-24T17:09:41Z | - |
dc.date.available | 2015-04-24T17:09:41Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104873 | - |
dc.description.abstract | BACKGROUND: Dystroglycan (DG) is a recently focused adhesion molecule with possible roles in cancer development and progression. We investigated correlations between alpha-DG expression and prognosis in gastric carcinoma with liver metastasis. METHODS: For 40 patients with gastric adenocarcinoma and liver-only metastasis, alpha-DG expression was determined by immunohistochemistry in paraffin-embedded surgical specimens of resected stomach tumor, resected liver metastasis, and their normal counterpart tissues. Correlations between alpha-DG expression and prognosis were retrospectively analyzed. RESULTS: alpha-DG expression was higher in primary gastric cancer (P = 0.006) and lower in liver metastasis (P = 0.002) than in each normal counterpart. In primary stomach cancer, patients who had lower alpha-DG expression in tumors than in normal counterparts showed poor overall survival (OS) (P = 0.028). In contrast, in the liver, patients who had higher alpha-DG expression in tumors than in normal counterparts showed poor OS (P = 0.022). Also, higher alpha-DG expression in liver metastasis than in stomach tumors led to poor recurrence-free survival (P = 0.023) and OS (P = 0.056). CONCLUSIONS: This approach may be used to further understanding of the pathogenesis of liver metastasis from gastric cancer. Further studies are warranted to reveal the mechanisms of alpha-DG dysregulation in liver metastasis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 459~465 | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/metabolism | - |
dc.subject.MESH | Adenocarcinoma/mortality* | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Adenocarcinoma/surgery | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Catheter Ablation | - |
dc.subject.MESH | Dystroglycans/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrectomy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Liver/metabolism | - |
dc.subject.MESH | Liver Neoplasms/metabolism* | - |
dc.subject.MESH | Liver Neoplasms/mortality | - |
dc.subject.MESH | Liver Neoplasms/secondary | - |
dc.subject.MESH | Liver Neoplasms/surgery | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/mortality | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Stomach/metabolism | - |
dc.subject.MESH | Stomach Neoplasms/metabolism | - |
dc.subject.MESH | Stomach Neoplasms/mortality* | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Stomach Neoplasms/surgery | - |
dc.title | Increments of alpha-dystroglycan expression in liver metastasis correlate with poor survival in gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | YONGWHA MOON | - |
dc.contributor.googleauthor | SUN YOUNG RHA | - |
dc.contributor.googleauthor | XIANGLAN ZHANG | - |
dc.contributor.googleauthor | HEI-CHEUL JEUNG | - |
dc.contributor.googleauthor | WOO ICK YANG | - |
dc.contributor.googleauthor | OBIN KWON | - |
dc.contributor.googleauthor | JAE HEON JEONG | - |
dc.contributor.googleauthor | SUNG HAH CHEON | - |
dc.contributor.googleauthor | NAE CHOON YOO | - |
dc.contributor.googleauthor | HYUN CHEOL CHUNG | - |
dc.identifier.doi | 10.1002/jso.21347 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01370 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A02457 | - |
dc.contributor.localId | A03714 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A00234 | - |
dc.contributor.localId | A03794 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J01762 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.pmid | 19598149 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jso.21347/abstract | - |
dc.subject.keyword | dystroglycan | - |
dc.subject.keyword | gastric carcinoma | - |
dc.subject.keyword | liver metastasis | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Moon, Yong Wha | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Yoo, Nae Choon | - |
dc.contributor.alternativeName | Jung, Jae Hun | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.alternativeName | Kwon, O Bin | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.affiliatedAuthor | Moon, Yong Wha | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Yoo, Nae Choon | - |
dc.contributor.affiliatedAuthor | Jung, Jae Hun | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Kwon, O Bin | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.citation.volume | 100 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 459 | - |
dc.citation.endPage | 465 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, Vol.100(6) : 459-465, 2009 | - |
dc.identifier.rimsid | 42536 | - |
dc.type.rims | ART | - |
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