Cited 19 times in
Role of T-type Ca2+ Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle
DC Field | Value | Language |
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dc.contributor.author | 안덕선 | - |
dc.contributor.author | 이시은 | - |
dc.contributor.author | 이영호 | - |
dc.date.accessioned | 2015-04-24T17:09:19Z | - |
dc.date.available | 2015-04-24T17:09:19Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104862 | - |
dc.description.abstract | Although extracellular Ca2+ entry through the voltage-dependent Ca2+ channels plays an important role in the spontaneous phasic contractions of the pregnant rat myometrium, the role of the T-type Ca2+ channels has yet to be fully identified. The aim of this study was to investigate the role of the T-type Ca2+ channel in the spontaneous phasic contractions of the rat myometrium. Spontaneous phasic contractions and [Ca2+]i were measured simultaneously in the longitudinal strips of female Sprague-Dawley rats late in their pregnancy (on day 18~20 of gestation: term=22 days). The expression of T-type Ca2+ channel mRNAs or protein levels was measured. Cumulative addition of low concentrations (<1 micrometer) of nifedipine, a L-type Ca2+ channel blocker, produced a decrease in the amplitude of the spontaneous Ca2+ transients and contractions with no significant change in frequency. The mRNAs and proteins encoding two subunits (alpha1G, alpha1H) of the T-type Ca2+ channels were expressed in longitudinal muscle layer of rat myometrium. Cumulative addition of mibefradil, NNC 55-0396 or nickel induced a concentration-dependent inhibition of the amplitude and frequency of the spontaneous Ca2+ transients and contractions. Mibefradil, NNC 55-0396 or nickel also attenuated the slope of rising phase of spontaneous Ca2+ transients consistent with the reduction of the frequency. It is concluded that T-type Ca2+ channels are expressed in the pregnant rat myometrium and may play a key role for the regulation of the frequency of spontaneous phasic contractions. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 241~249 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Role of T-type Ca2+ Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Si-Eun Lee | - |
dc.contributor.googleauthor | Duck-Sun Ahn | - |
dc.contributor.googleauthor | Young-Ho Lee | - |
dc.identifier.doi | 10.4196/kjpp.2009.13.3.241 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02223 | - |
dc.contributor.localId | A02941 | - |
dc.contributor.localId | A02968 | - |
dc.relation.journalcode | J02104 | - |
dc.identifier.eissn | 2093-3827 | - |
dc.identifier.pmid | 19885043 | - |
dc.subject.keyword | Calcium channels | - |
dc.subject.keyword | Mibefradil | - |
dc.subject.keyword | NNC 55-0396 | - |
dc.subject.keyword | Nickel | - |
dc.subject.keyword | Spontaneous contractility | - |
dc.contributor.alternativeName | Ahn, Duk Sun | - |
dc.contributor.alternativeName | Lee, Si Eun | - |
dc.contributor.alternativeName | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Ahn, Duk Sun | - |
dc.contributor.affiliatedAuthor | Lee, Si Eun | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 241 | - |
dc.citation.endPage | 249 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.13(3) : 241-249, 2009 | - |
dc.identifier.rimsid | 42530 | - |
dc.type.rims | ART | - |
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