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Prognostic value of thymidine phosphorylase expression for pancreatic cancer.

 Hong SP  ;  Shin SK  ;  Bang S  ;  Park SW  ;  Chung JB  ;  Lee WJ  ;  Song SY 
 HEPATO-GASTROENTEROLOGY, Vol.56(93) : 1178-1182, 2009 
Journal Title
Issue Date
Carcinoma, Pancreatic Ductal/enzymology* ; Carcinoma, Pancreatic Ductal/pathology ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Pancreatic Neoplasms/enzymology* ; Pancreatic Neoplasms/pathology ; Predictive Value of Tests ; Prognosis ; Statistics, Nonparametric ; Survival Rate ; Thymidine Phosphorylase/metabolism*
BACKGROUND/AIMS: Thymidine phosphorylase (TP) has an angiogenic activity, but the prognostic value of TP has not been fully validated for pancreatic cancer. The aim of this study was to evaluate TP expression according to clinicopathological parameters to define its prognostic value for pancreatic cancer. METHODOLOGY: Forty-three patients with pancreatic ductal adenocarcinoma were examined retrospectively. TP expression and intratumoral microvessel density (IMD) were evaluated by immunohistochemistry. TP expression was analyzed according to clinicopathological parameters. RESULTS: Twenty-eight (65%) of 42 cases showed diffuse cytoplasmic and nucleic TP staining. IMD was significantly higher in TP-positive tumors than in TP-negative tumors (27.7 +/- 8.9 vs. 18.1 +/- 4.4, p < 0.01). TP levels were significantly higher in T3 and T4 tumors than in T1 and T2 tumors (56% vs. 9.3%, respectively, p < 0.05). Patients with TP-positive tumors more frequently developed hepatic recurrence than those with TP-negative tumors after resection (p < 0.01). Patients with TP-positive tumors had a shorter survival than patients with TP-negative tumors (p < 0.05). CONCLUSION: TP expression can be used as a predictor of hepatic recurrence and as an unfavorable prognostic factor for pancreatic cancer
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Chung, Jae Bock(정재복)
Hong, Sung Pil(홍성필)
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