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Development of epigallocatechin gallate-eluting polymeric stent and its physicochemical, biomechanical and biological evaluations

DC FieldValueLanguage
dc.contributor.author박종철-
dc.contributor.author한동욱-
dc.date.accessioned2015-04-24T17:04:43Z-
dc.date.available2015-04-24T17:04:43Z-
dc.date.issued2009-
dc.identifier.issn1748-6041-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104718-
dc.description.abstractLocalized drug delivery from drug-eluting stents has been accepted as one of the most promising treatment methods for preventing restenosis after stenting. However, hypersensitivity reactions caused by their nonresorbable polymer coatings and bare-metal stents may result in serious clinical sequelae. Epigallocatechin-3-O-gallate (EGCG), the predominant catechin from tea, has been shown to exert anti-thrombotic, anti-inflammatory and anti-proliferative activities. in this study, it was hypothesized that sustainedly released EGCG from biodegradable poly(lactide-co-epsilon-caprolactone, PLCL) would suppress the proliferation of vascular smooth muscle cells (VSMCs). EGCG-releasing PLCL (E-PLCL) was prepared by blending PLCL with EGCG. the surface morphology, roughness and melting temperature of PLCL were not changed despite EGCG addition. EGCG was uniformly dispersed into E-PLCL and sustainedly released for periods up to 7 days by controlled diffusion rather than PLCL degradation. Moreover, EGCG did not affect tensile strength at break, but significantly increased the elastic modulus of PLCL. the proliferation of VSMCs onto E-PLCL was significantly suppressed although the cell attachment onto E-PLCL had been higher than that onto PLCL. on the other hand, EGCG-eluting polymeric stents were prepared with neither cracks nor webbings between struts, and their structural integrity was maintained without delamination or destruction. These results suggest that E-PLCL can be potentially applied for fabricating an EGCG-eluting vascular stent, namely an EGCG-eluting polymeric stent, or even an EGCG-releasing polymer-coated metal stent, to prevent thrombosis, inflammation and in-stent restenosis.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBIOMEDICAL MATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAorta, Thoracic/cytology-
dc.subject.MESHCaproates-
dc.subject.MESHCatechin/analogs & derivatives-
dc.subject.MESHCatechin/metabolism-
dc.subject.MESHDrug Delivery Systems/adverse effects-
dc.subject.MESHDrug-Eluting Stents*-
dc.subject.MESHLactones-
dc.subject.MESHMale-
dc.subject.MESHMuscle, Smooth, Vascular/cytology-
dc.subject.MESHMuscle, Smooth, Vascular/metabolism-
dc.subject.MESHMyocytes, Smooth Muscle/cytology-
dc.subject.MESHMyocytes, Smooth Muscle/metabolism-
dc.subject.MESHPolymers/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHStents/adverse effects*-
dc.subject.MESHTensile Strength-
dc.titleDevelopment of epigallocatechin gallate-eluting polymeric stent and its physicochemical, biomechanical and biological evaluations-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학)-
dc.contributor.googleauthorDong-Wook Han-
dc.contributor.googleauthorJun Jae Lee-
dc.contributor.googleauthorDuk-Young Jung-
dc.contributor.googleauthorJong-Chul Park-
dc.contributor.googleauthorSuong-Hyu Hyon-
dc.identifier.doi10.1088/1748-6041/4/4/044104-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01662-
dc.contributor.localIdA04275-
dc.relation.journalcodeJ00318-
dc.identifier.eissn1748-605X-
dc.identifier.pmid19584425-
dc.identifier.urlhttp://stacks.iop.org/1748-6041/4/044104-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.alternativeNameHan, Dong Wook-
dc.contributor.affiliatedAuthorPark, Jong Chul-
dc.contributor.affiliatedAuthorHan, Dong Wook-
dc.citation.volume4-
dc.citation.number4-
dc.citation.startPage044104-
dc.identifier.bibliographicCitationBIOMEDICAL MATERIALS, Vol.4(4) : 044104, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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