Cited 13 times in
Development of epigallocatechin gallate-eluting polymeric stent and its physicochemical, biomechanical and biological evaluations
DC Field | Value | Language |
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dc.contributor.author | 박종철 | - |
dc.contributor.author | 한동욱 | - |
dc.date.accessioned | 2015-04-24T17:04:43Z | - |
dc.date.available | 2015-04-24T17:04:43Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1748-6041 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104718 | - |
dc.description.abstract | Localized drug delivery from drug-eluting stents has been accepted as one of the most promising treatment methods for preventing restenosis after stenting. However, hypersensitivity reactions caused by their nonresorbable polymer coatings and bare-metal stents may result in serious clinical sequelae. Epigallocatechin-3-O-gallate (EGCG), the predominant catechin from tea, has been shown to exert anti-thrombotic, anti-inflammatory and anti-proliferative activities. in this study, it was hypothesized that sustainedly released EGCG from biodegradable poly(lactide-co-epsilon-caprolactone, PLCL) would suppress the proliferation of vascular smooth muscle cells (VSMCs). EGCG-releasing PLCL (E-PLCL) was prepared by blending PLCL with EGCG. the surface morphology, roughness and melting temperature of PLCL were not changed despite EGCG addition. EGCG was uniformly dispersed into E-PLCL and sustainedly released for periods up to 7 days by controlled diffusion rather than PLCL degradation. Moreover, EGCG did not affect tensile strength at break, but significantly increased the elastic modulus of PLCL. the proliferation of VSMCs onto E-PLCL was significantly suppressed although the cell attachment onto E-PLCL had been higher than that onto PLCL. on the other hand, EGCG-eluting polymeric stents were prepared with neither cracks nor webbings between struts, and their structural integrity was maintained without delamination or destruction. These results suggest that E-PLCL can be potentially applied for fabricating an EGCG-eluting vascular stent, namely an EGCG-eluting polymeric stent, or even an EGCG-releasing polymer-coated metal stent, to prevent thrombosis, inflammation and in-stent restenosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BIOMEDICAL MATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Aorta, Thoracic/cytology | - |
dc.subject.MESH | Caproates | - |
dc.subject.MESH | Catechin/analogs & derivatives | - |
dc.subject.MESH | Catechin/metabolism | - |
dc.subject.MESH | Drug Delivery Systems/adverse effects | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Lactones | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Muscle, Smooth, Vascular/cytology | - |
dc.subject.MESH | Muscle, Smooth, Vascular/metabolism | - |
dc.subject.MESH | Myocytes, Smooth Muscle/cytology | - |
dc.subject.MESH | Myocytes, Smooth Muscle/metabolism | - |
dc.subject.MESH | Polymers/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Stents/adverse effects* | - |
dc.subject.MESH | Tensile Strength | - |
dc.title | Development of epigallocatechin gallate-eluting polymeric stent and its physicochemical, biomechanical and biological evaluations | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학) | - |
dc.contributor.googleauthor | Dong-Wook Han | - |
dc.contributor.googleauthor | Jun Jae Lee | - |
dc.contributor.googleauthor | Duk-Young Jung | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.contributor.googleauthor | Suong-Hyu Hyon | - |
dc.identifier.doi | 10.1088/1748-6041/4/4/044104 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01662 | - |
dc.contributor.localId | A04275 | - |
dc.relation.journalcode | J00318 | - |
dc.identifier.eissn | 1748-605X | - |
dc.identifier.pmid | 19584425 | - |
dc.identifier.url | http://stacks.iop.org/1748-6041/4/044104 | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.alternativeName | Han, Dong Wook | - |
dc.contributor.affiliatedAuthor | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | Han, Dong Wook | - |
dc.citation.volume | 4 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 044104 | - |
dc.identifier.bibliographicCitation | BIOMEDICAL MATERIALS, Vol.4(4) : 044104, 2009 | - |
dc.identifier.rimsid | 52883 | - |
dc.type.rims | ART | - |
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