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Weekly docetaxel in patients with platinum-refractory metastatic or recurrent squamous cell carcinoma of the head and neck

Authors
 Byoung Chul Cho  ;  Ki Chang Keum  ;  Sang Joon Shin  ;  Hye Jin Choi  ;  Young Joo Lee  ;  Se Hun Kim  ;  Eun Chang Choi  ;  Joo Hang Kim 
Citation
 Cancer Chemotherapy and Pharmacology, Vol.65(1) : 27-32, 2009 
Journal Title
 Cancer Chemotherapy and Pharmacology 
ISSN
 0344-5704 
Issue Date
2009
Abstract
BACKGROUND: The objective of the study was to investigate the efficacy and tolerability of weekly docetaxel in patients with platinum-refractory recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). METHODS: Patients fulfilling the following criteria were enrolled: histologically confirmed SCCHN; documented progressive disease (PD) after platinum-based treatment; Eastern Cooperative Oncology Group (ECOG) 0-2; measurable disease; not candidates for local therapy. Docetaxel (35 mg/m(2)) was administered for 3 weeks, every 4 weeks for a maximum of 6 cycles. RESULTS: A total of 23 patients were treated. All patients were assessable for toxicity and response. The overall response rate was 13.0% (3/23) and disease control rate was 34.7% (8/23). Median progression-free and overall survival (OS) was 9 (95% CI, 7.6-10.4 weeks) and 29 weeks (95% CI, 10.8-47.1 weeks), respectively. Most common hematological toxicities were grade 1-2 anemia (6/23, 26.1%) and nonhematological toxicities were mild and manageable. There was no treatment-related death. CONCLUSION: Weekly docetaxel regimen had good clinical activity with an acceptable toxicity in patients with platinum-refractory SCCHN
Full Text
http://link.springer.com/article/10.1007%2Fs00280-009-0999-4
DOI
10.1007/s00280-009-0999-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
금기창(Keum, Ki Chang) ORCID logo https://orcid.org/0000-0003-4123-7998
김세헌(Kim, Se Heon)
김주항(Kim, Joo Hang)
신상준(Shin, Sang Joon) ORCID logo https://orcid.org/0000-0001-5350-7241
조병철(Cho, Byoung Chul) ORCID logo https://orcid.org/0000-0002-5562-270X
최은창(Choi, Eun Chang)
최혜진(Choi, Hye Jin) ORCID logo https://orcid.org/0000-0001-5917-1400
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104651
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