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기능성 소화 불량증 및 과민성 장 증후군 환자에서 세로토닌 수송 단백질 유전자와 GNβ3 C825T 유전자의 다형성

Other Titles
 Serotonin Transporter Gene and G-protein β3 C825T Gene Polymorphism in Patients with Functional Dyspepsia and Irritable Bowel Syndrome 
 박혜연  ;  장재훈  ;  이영주  ;  박효진  ;  이상인 
 Korean Journal of Neurogastroenterology and Motility (대한소화관운동학회지), Vol.15(1) : 58-64, 2009 
Journal Title
 Korean Journal of Neurogastroenterology and Motility (대한소화관운동학회지) 
Issue Date
Serotonin transporter ; G-protein ; Functional dyspepsia ; Irritable bowel syndrome
Background/Aims: The pathogenesis of functional dyspepsia (FD) and irritable bowel syndrome (IBS) is considered to be multifactorial. Recently, several candidate genetic studies have suggested that serotonin transporter (SERT) gene polymorphism and G-protein β3 (GNβ3) C825T gene polymorphism are associated with FD and IBS. The aim of this study was to investigate SERT and GNβ3 C825T gene polymorphism in Korean patients with functional gastrointestinal disorder (FGID) including FD and IBS. Methods: SERT and GNβ3 C825T gene polymorphism was assessed by polymerase chain reaction in serum samples from 62 patients with upper FGID (including 24 patients with FD) 49 patients with lower FGID (including 26 patients with IBS), and 70 healthy adults. Results: There were no significant differences in the genetic polymorphism among the upper and lower FGID, FD, IBS and the control group of patients. Subtype analysis revealed that the GNβ3 C825T C/C genotype tended to be associated with diarrhea-predominant IBS compared to the T/T genotype (p=0.049, OR=5.333 95% CI: 1.008-28.205). Conclusion: SERT and GNβ3 C825T polymorphism does not appear to be associated with FGID including FD and IBS in Koreans.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hye Yeon(박혜연)
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Sang In(이상인)
Lee, Young Joo(이영주)
Jahng, Jae Hoon(장재훈)
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