Cited 3 times in
Identification of significant regional genetic variations using continuous CNV values in aCGH data
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기열 | - |
dc.contributor.author | 김진 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 이귀연 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.date.accessioned | 2015-04-24T17:01:40Z | - |
dc.date.available | 2015-04-24T17:01:40Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0888-7543 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104621 | - |
dc.description.abstract | Array comparative genomic hybridization (aCGH) provides a technique to survey the human genome for chromosomal aberrations in disease. The identification of genomic regions with aberrations may clarify the initiation and progression of cancer, improve diagnostic and prognostic accuracy, and guide therapy. The analysis of variance (ANOVA) model is widely used to detect differentially expressed genes after accounting for common sources of variation in microarray analysis. In this study, we propose a method, shifted ANOVA, to detect significantly altered regions. This method, based on the standard ANOVA, analyzes changes in copy number variation for regions. The selected regions have the group effect only, but no effect within samples and no interactive effects. The performance of the proposed method is evaluated from the homogeneity and classification accuracies of the selected regions. Shifted ANOVA may identify new candidate genes neighboring known because it detects significantly altered chromosomal regions, rather than independent probes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 317~323 | - |
dc.relation.isPartOf | GENOMICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Chromosome Aberrations | - |
dc.subject.MESH | Colorectal Neoplasms/genetics | - |
dc.subject.MESH | Comparative Genomic Hybridization/methods* | - |
dc.subject.MESH | Comparative Genomic Hybridization/statistics & numerical data | - |
dc.subject.MESH | DNA/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Dosage* | - |
dc.subject.MESH | Genetic Variation* | - |
dc.subject.MESH | Genome, Human/genetics* | - |
dc.subject.MESH | Genomics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intestinal Mucosa/cytology | - |
dc.subject.MESH | Leukocytes, Mononuclear/cytology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Models, Statistical | - |
dc.subject.MESH | Neoplasms | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis/methods* | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis/statistics & numerical data | - |
dc.subject.MESH | Sequence Analysis, DNA | - |
dc.title | Identification of significant regional genetic variations using continuous CNV values in aCGH data | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학) | - |
dc.contributor.googleauthor | Ki-Yeol Kim | - |
dc.contributor.googleauthor | Gui Youn Lee | - |
dc.contributor.googleauthor | Jin Kim | - |
dc.contributor.googleauthor | Hei-Cheul Jeung | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.identifier.doi | 10.1016/j.ygeno.2009.08.006 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00337 | - |
dc.contributor.localId | A02679 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A03794 | - |
dc.contributor.localId | A01009 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J00939 | - |
dc.identifier.eissn | 1089-8646 | - |
dc.identifier.pmid | 19699295 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0888754309001839 | - |
dc.subject.keyword | Array CGH | - |
dc.subject.keyword | Genomic variations | - |
dc.subject.keyword | Systematic aberrations | - |
dc.subject.keyword | Shifted ANOVA | - |
dc.subject.keyword | Chromosomal region | - |
dc.contributor.alternativeName | Kim, Ki Yeol | - |
dc.contributor.alternativeName | Kim, Jin | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Lee, Gui Youn | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Kim, Ki Yeol | - |
dc.contributor.affiliatedAuthor | Lee, Gui Youn | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Kim, Jin | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.citation.volume | 94 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 317 | - |
dc.citation.endPage | 323 | - |
dc.identifier.bibliographicCitation | GENOMICS, Vol.94(5) : 317-323, 2009 | - |
dc.identifier.rimsid | 52819 | - |
dc.type.rims | ART | - |
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