1 437

Cited 5 times in

Failing to achieve a nadir prostate-specific antigen after combined androgen blockade: predictive factors

Authors
 Seung Chol Park  ;  Joung Sik Rim  ;  Han Yong Choi  ;  Choung Soo Kim  ;  Sung Joon Hong  ;  Wun Jae Kim  ;  Sang Eun Lee  ;  Jae Mann Song  ;  Jin Han Yoon 
Citation
 INTERNATIONAL JOURNAL OF UROLOGY, Vol.16(8) : 670-675, 2009 
Journal Title
INTERNATIONAL JOURNAL OF UROLOGY
ISSN
 0919-8172 
Issue Date
2009
MeSH
Aged ; Aged, 80 and over ; Androgen Antagonists/therapeutic use* ; Disease Progression ; Gonadotropin-Releasing Hormone/analogs & derivatives* ; Humans ; Male ; Middle Aged ; Orchiectomy* ; Predictive Value of Tests ; Prostate-Specific Antigen/blood* ; Prostatic Neoplasms/blood* ; Prostatic Neoplasms/therapy* ; Retrospective Studies ; Time Factors
Keywords
androgen ; progression ; prostate cancer ; prostate‐specific antigen
Abstract
OBJECTIVES: To determine the optimal cut-off of a nadir prostate-specific antigen (PSA) for prediction of progression within 24 months after combined androgen blockade (CAB) and to analyze predictive factors of failing to achieve the nadir PSA.

METHODS: We retrospectively reviewed the medical records of 343 patients with prostate cancer treated with CAB from 2000 to 2005. We determined the nadir PSA level that predicts progression to hormone refractory prostate cancer (HRPC) at 24 months after CAB. Predictive factors for failing to achieve a determined nadir PSA were analyzed.

RESULTS: Mean age was 74.0 years. Mean follow up was 42.1 month. Seventy-seven patients experienced progression to HRPC. A nadir PSA of 1.0 ng/mL predicts progression to HRPC at 24 months. Predictive factors for failing to achieve a nadir PSA of 1.0 ng/mL or less include pretreatment PSA, percentage positive biopsy core, Gleason score, serum hemoglobin, stage, and extent of bone metastasis in univariate analysis. Pretreatment PSA (>50 ng/mL) and serum hemoglobin (<12 g/dL) were significant factors to predict failing to achieve a nadir PSA of 1.0 ng/mL or less in logistic regression analysis.

CONCLUSIONS: A nadir PSA of 1.0 ng/mL can predict progression to HRPC after CAB. Pretreatment PSA and serum hemoglobin are significant predictors of failing to achieve a nadir PSA of 1.0 ng/mL or less.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1442-2042.2009.02329.x/abstract
DOI
10.1111/j.1442-2042.2009.02329.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104618
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links