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Preventive effects of oligomerized polyphenol on estradiol-induced prostatitis in rats

 Dong Suk Kim  ;  Eun Jin Lee  ;  Kang Su Cho  ;  So Jung Yoon  ;  Young Hoon Lee  ;  Sung Joon Hong 
 YONSEI MEDICAL JOURNAL, Vol.50(3) : 391-398, 2009 
Journal Title
Issue Date
Animals ; Blotting, Western ; Body Weight/drug effects ; Estradiol/adverse effects* ; Flavonoids/therapeutic use* ; Immunoassay ; Male ; Phenols/therapeutic use* ; Polyphenols ; Prostate/drug effects ; Prostate/pathology ; Prostatitis/chemically induced* ; Prostatitis/metabolism ; Prostatitis/prevention & control* ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Nonbacterial prostatitis ; inflammation ; oligonol ; oxidative stress ; polyphenol
PURPOSE: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS, NIH category III) accounts for 90-95% of prostatitis cases. However, standard treatment has not yet been established. It is known that polyphenols have an inhibitory effect on inflammation by their antioxidative capacity, and oligonol, a polyphenol derivative, has much higher bioavailability and bioactivity than common polyphenols. We investigated the anti-inflammatory effects and mechanisms of oligonol in estradiol-induced prostatitis rat models. MATERIALS AND METHODS: Prostatitis was induced by 17 beta-estradiol (E2) and dihydrotestosterone (DHT) in Wistar male rats (n = 20). Ten rats were placed in the oligonol-treated group and 10 in the E2 + DHT-treated group. The other 10 rats were also included as normal control group. Oligonol (60 mg/kg/day) was administered via gavage tube for 4 weeks. Superoxide dismutase (SOD), glutathione peroxidase (GPx), and tumor necrosis factor-alpha (TNF-alpha) were quantified, and phosphorylation of IkappaBa and histological changes were also evaluated in prostatic tissue. RESULTS: The SOD and GPx activity showed tendencies to increase in the oligonol-treated group compared to the normal control group. TNF-alpha expression was slightly reduced in the oligonol-treated group. Western blotting demonstrated that phosphorylation of IkappaBa in the oligonol-treated group was significantly lower than in the normal control group. The E2 + DHT-treated group revealed severe atrophy of acinar epithelial cells and infiltration of leukocytes and lymphocytes in the prostate, however, the oligonol-treated group showed overall reduction in inflammatory features. CONCLUSION: This study demonstrates that oligonol improves estradiol-induced non-bacterial prostatitis by regulating phosphorylation of IkappaBa. These findings suggest that oligonol has a beneficial effect on prevention and treatment of CP/CPPS
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Suk(김동석)
Lee, Young Hoon(이영훈)
Cho, Kang Su(조강수) ORCID logo https://orcid.org/0000-0002-3500-8833
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
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