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Expression of Wnt target genes in solid pseudopapillary tumor of the pancreas: a pilot study

 Chang Moo Kang  ;  Hyun Ki Kim  ;  Hoguen Kim  ;  Gi Hong Choi  ;  Kyung Sik Kim  ;  Jin Sub Choi  ;  Woo Jung Lee 
 PANCREAS, Vol.38(2) : 53-59, 2009 
Journal Title
Issue Date
Adolescent ; Adult ; Carcinoma, Papillary/metabolism* ; Carcinoma, Papillary/pathology ; Cyclin D1/analysis ; Cyclin D1/genetics ; Female ; Gene Expression ; Genes, myc ; Humans ; Immunohistochemistry ; Ki-67 Antigen/analysis ; Male ; Matrix Metalloproteinase 7/analysis ; Matrix Metalloproteinase 7/genetics ; Middle Aged ; Pancreatic Neoplasms/metabolism* ; Pancreatic Neoplasms/pathology ; Pilot Projects ; Wnt Proteins/physiology* ; beta Catenin/analysis ; beta Catenin/genetics
solid pseudopapillary tumor ; Wnt ; pancreas ; immunohistochemistry
OBJECTIVES: Solid pseudopapillary tumor (SPT) of the pancreas is very rare. This study was performed to analyze the expression of Wnt signal target genes (matrix metalloproteinase-7 [MMP-7], cyclin-D1, and c-myc) and Ki-67 in resected SPTs to determine their clinicopathologic characteristics according to their expression.

METHODS: From January 1995 to December 2005, 23 patients underwent pancreatic resections for SPT of the pancreas. Among 23 formalin-fixed, paraffin-embedded tissues, 12 were evaluated as a pilot study. Immunohistochemistry was performed using various detection and antigen retrieval methods to detect MMP-7, cyclin-D1, c-myc, and Ki-67. The expression of Wnt target genes was correlated with clinicopathologic features of the patients.

RESULTS: Solid pseudopapillary tumors of the pancreas always showed cytoplasmic/nuclear accumulation of [beta]-catenin, frequent expression of cyclin-D1, and low proliferation index. MMP-7, cyclin-D1, c-myc, and Ki-67 were not correlated with microscopic features suggesting malignant potential (P > 0.05). Tumor size was closely related to microscopic features of malignant potential and apparently has an inverse relationship with the expression of cyclin-D1 and Ki-67 (P < 0.05).

CONCLUSIONS: Low proliferative index and associated MMP-7 expression may cause an unpredictable clinical course in this tumor. Subtle changes in the intracellular environment, not pathologic (morphologic) changes, may elucidate the unpredictable clinical course of this tumor.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Kim, Hogeun(김호근)
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
Choi, Jin Sub(최진섭)
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