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Effect-site concentration of remifentanil for laryngeal mask airway insertion during target-controlled infusion of propofol

Authors
 M. K. Kim  ;  J. W. Lee  ;  D. J. Jang  ;  O. Y. Shin  ;  S. B. Nam 
Citation
 ANAESTHESIA, Vol.64(2) : 136-140, 2009 
Journal Title
 ANAESTHESIA 
ISSN
 0003-2409 
Issue Date
2009
MeSH
Adult ; Analgesics, Opioid/administration & dosage* ; Anesthetics, Intravenous/administration & dosage* ; Blood Pressure/drug effects ; Drug Administration Schedule ; Heart Rate/drug effects ; Humans ; Infusions, Intravenous ; Laryngeal Masks* ; Middle Aged ; Piperidines/administration & dosage* ; Propofol/administration & dosage* ; Young Adult
Abstract
The purpose of this study was to determine the effect-site concentration of remifentanil that would provide optimal conditions for successful laryngeal mask airway insertion during a target-controlled infusion (TCI) of propofol at 3.5 microg.ml(-1) without the use of neuromuscular blockade. Five minutes after propofol infusion, remifentanil was infused at a dose determined by a modified Dixon's up-and-down method. Five minutes after remifentanil infusion, the laryngeal mask was inserted. The effect-site concentration of remifentanil for successful laryngeal mask insertion in 50% of adults (EC(50)) was 3.04 (SD 0.49) ng.ml(-1) during a TCI of 3.5 microg.ml(-1) propofol without neuromuscular blockade. From the probit analysis, the EC(50) and EC(95) of remifentanil were 2.84 ng.ml(-1) (95% CI 2.09-3.57 ng.ml(-1)) and 3.79 ng.ml(-1) (95% CI 3.26-9.25 ng.ml(-1)), respectively.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2008.05707.x/abstract
DOI
10.1111/j.1365-2044.2008.05707.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Nam, Sang Beom(남상범) ORCID logo https://orcid.org/0000-0002-9704-1866
Lee, Jong Wha(이종화)
Chang, Dong Jin(장동진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104468
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