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The effect of oral and IV ramosetron on postoperative nausea and vomiting in patients undergoing gynecological laparoscopy with total intravenous anesthesia.

Authors
 DONGCHUL LEE  ;  JI YOUNG KIM  ;  JIN WOO SHIN  ;  CHUN HOE KU  ;  YEON SOO PARK  ;  HYUN JEONG KWAK 
Citation
 JOURNAL OF ANESTHESIA, Vol.23(1) : 46-50, 2009 
Journal Title
 JOURNAL OF ANESTHESIA 
ISSN
 0913-8668 
Issue Date
2009
MeSH
Administration, Oral ; Adolescent ; Adult ; Anesthesia, Intravenous* ; Antiemetics/administration & dosage ; Antiemetics/therapeutic use* ; Benzimidazoles/administration & dosage ; Benzimidazoles/therapeutic use* ; Double-Blind Method ; Female ; Gynecologic Surgical Procedures* ; Humans ; Hypnotics and Sedatives ; Injections, Intravenous ; Laparoscopy* ; Midazolam ; Middle Aged ; Postoperative Nausea and Vomiting/prevention & control* ; Premedication ; Young Adult
Keywords
Gynecological laparoscopy ; Postoperative nausea and vomiting ; Ramosetron
Abstract
PURPOSE: Ramosetron can be administered orally as well as intravenously. We investigated the effect of oral ramosetron on postoperative nausea and vomiting (PONV) in patients undergoing gynecological laparoscopy. METHODS: One hundred and twenty women were allocated randomly to one of three groups (n = 40 in each) to receive saline (control), 0.1 mg oral ramosetron (PO), or 0.3 mg IV ramosetron (IV). Total intravenous anesthesia (TIVA) with propofol and remifentanil was used in all patients. RESULTS: The incidence of complete response (no PONV, no rescue) in the control, IV, and PO groups was: 65%, 90%, and 87.5%, respectively, during the first 1 h; and 67.5%, 87.5%, and 80%, respectively, during 1 to 24 h. CONCLUSION: The effect of oral ramosetron 0.1 mg was comparable to that of IV ramosetron 0.3 mg on the prevention of PONV in women undergoing gynecological laparoscopy with TIVA. Both the oral and IV forms were effective at preventing PONV during the first 1 h after surgery
Full Text
http://link.springer.com/article/10.1007%2Fs00540-008-0693-4
DOI
10.1007/s00540-008-0693-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji Young(김지영) ORCID logo https://orcid.org/0000-0001-5822-0338
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104464
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