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Spread of CTX-M-type extended-spectrum beta-lactamases among bloodstream isolates of Escherichia coli and Klebsiella pneumoniae from a Korean hospital

Authors
 Sang-Guk Lee  ;  Seok Hoon Jeong  ;  Hyukmin Lee  ;  Chang Ki Kim  ;  Yangsoon Lee  ;  Eunmi Koh  ;  Yunsop Chong  ;  Kyungwon Lee 
Citation
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.63(1) : 76-80, 2009 
Journal Title
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 
ISSN
 0732-8893 
Issue Date
2009
MeSH
Bacteremia/epidemiology ; Bacteremia/microbiology ; Bacterial Proteins/genetics ; Base Sequence ; Drug Resistance, Bacterial/genetics ; Escherichia coli/enzymology* ; Escherichia coli/genetics ; Escherichia coli Infections/epidemiology* ; Escherichia coli Infections/microbiology ; Escherichia coli Proteins/genetics ; Hospitals ; Humans ; Klebsiella Infections/epidemiology* ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/enzymology* ; Klebsiella pneumoniae/genetics ; Korea ; Microbial Sensitivity Tests ; Molecular Sequence Data ; Phenotype ; Prevalence ; beta-Lactamases/genetics*
Keywords
CTX-M-14 ; CTX-M-15 ; CTX-M-24 ; CTX-M-65 ; CTX-M-27 ; CTX-M-32 ; Korea
Abstract
This study was to determine the prevalence and characteristics of CTX-M-type extended-spectrum beta-lactamases (ESBLs) in nonduplicate Escherichia coli (n=760) and Klebsiella pneumoniae (n=379) bloodstream isolates collected during January 2005 to October 2007 at a university hospital (2000 beds) in Seoul, Korea. Antimicrobial susceptibilities were determined by disk diffusion and agar dilution methods. The double-disk synergy test detected ESBLs in 8.7% (66/760) of E. coli and 11.3% (43/379) of K. pneumoniae isolates. Polymerase chain reaction detected bla(CTX-M) in 60/66 (90.9%) E. coli and 9/43 (20.9%) K. pneumoniae isolates with the ESBL phenotype. CTX-M-14 was the most common type of CTX-M ESBLs in both E. coli (n=32) and K. pneumoniae (n=6). CTX-M-15 was the 2nd most common type of CTX-M ESBLs in E. coli (n=22), but it was not detected in K. pneumoniae. In addition, CTX-M-24 (n=2), CTX-M-65 (n=2), CTX-M-27 (n=1), and CTX-M-32 (n=1) were detected for the 1st time in Korea.
Full Text
http://www.sciencedirect.com/science/article/pii/S0732889308004021
DOI
10.1016/j.diagmicrobio.2008.09.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Eun Mi(고은미)
Kim, Chang Ki(김창기)
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Lee, Yang Soon(이양순)
Lee, Hyuk Min(이혁민) ORCID logo https://orcid.org/0000-0002-8523-4126
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Chong, Yun Sop(정윤섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104431
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