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Carbapenem 내성 Acinetobacter spp.의 내성 기전

Other Titles
 Mechanisms of Acquiring Carbapenem-resistance in Acinetobacter Species 
Authors
 정석훈 
Citation
 Korean Journal of Clinical Microbiology (대한임상미생물학회지), Vol.12(1) : 1-5, 2009 
Journal Title
 Korean Journal of Clinical Microbiology (대한임상미생물학회지) 
ISSN
 2288-0585 
Issue Date
2009
Keywords
Acinetobacter ; OXA carbapenemase ; OXA51 ; OXA-23 ; Metallo-β-lactamase ; Outer membrane protein ; AdeABC efflux pump
Abstract
A rapid dissemination of carbapenem-resistant Acinetobacter spp. represents a significant clinical threat. Production of OXA carbapenemases and metallo-β-lactamases (MBLs) is the most important mechanism in acquiring carbapenem resistance in Acinetobacter spp. Carbapenem resistance has also ascribed to nonenzymatic mechanisms, including changes in outer membrane proteins, alterations in the affinity or expression of penicillin-binding proteins, and overexpression of efflux pumps. The most important mechanism in A. baumannii isolates from Korea is the production of OXA-23, while that in other species of Acinetobacter is the production of metallo-β-lactamases
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104429
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