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The first case of antibiotic-associated colitis by Clostridium difficile PCR Ribotype 027 in Korea

Authors
 Chung Hyun Tae  ;  Sung-Ae Jung  ;  Hyun Joo Song  ;  Seong-Eun Kim  ;  Hee Jung Choi  ;  Miae Lee  ;  Yusun Hwang  ;  Heejung Kim  ;  Kyungwon Lee 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.24(3) : 520-524, 2009 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2009
MeSH
Accidents, Traffic ; Acute Kidney Injury/diagnosis ; Antitubercular Agents/therapeutic use ; Base Sequence ; Clostridium difficile/classification* ; Clostridium difficile/genetics ; Clostridium difficile/isolation & purification ; Enterocolitis, Pseudomembranous/diagnosis* ; Enterocolitis, Pseudomembranous/drug therapy ; Enterocolitis, Pseudomembranous/microbiology* ; Female ; Humans ; Korea ; Middle Aged ; Molecular Sequence Data ; Polymerase Chain Reaction ; Ribotyping ; Shock, Septic/diagnosis
Keywords
Enterocolitis ; Pseudomembranous ; Clostridium difficile ; Ribotype 027
Abstract
Clostridium difficile (C. difficile) is a common causative agent of pseudomembranous colitis (PMC). C. difficile-associated diarrhea (CDAD) ranges from mild diarrhea to life threatening PMC. Recently, a highly virulent strain of C. difficile polymerase chain reaction ribotype 027 was found in North America, Europe, and Japan. A 52-yr-old woman with anti-tuberculosis medication and neurogenic bladder due to traffic accident experienced five episodes of C. difficile PMC after taking antibiotics for pneumonia along with septic shock and acute renal failure. She was readmitted to the intensive care unit and treated with oral vancomycin with refractory of oral metronidazole, inotropics and probiotics for over 60 days. C. difficile isolated both at the first and the last admission was identified as C. difficile ribotype 027 by ribotyping, toxinotyping, and tcdC gene sequencing, which turned out the same pathogen as the epidemic hypervirulent B1/NAP1 strain. This is the first case of C. difficile PCR ribotype 027 in Korea. After discharge, she was maintained on probiotics and rifaximin for 3 weeks. She had no relapse for 6 months
Files in This Item:
T200902828.pdf Download
DOI
10.3346/jkms.2009.24.3.520
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0002-0190-703X
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104425
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