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Dosimetric comparisons of three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and helical tomotherapy in whole abdominopelvic radiotherapy for gynecologic malignancy

Authors
 Yong Bae Kim  ;  Joo Ho Kim  ;  Kyung Keun Jeong  ;  Jinsil Seong  ;  Chang Ok Suh  ;  Gwi Eon Kim 
Citation
 TECHNOLOGY IN CANCER RESEARCH & TREATMENT, Vol.8(5) : 369-377, 2009 
Journal Title
 TECHNOLOGY IN CANCER RESEARCH & TREATMENT 
ISSN
 1533-0346 
Issue Date
2009
MeSH
Abdominal Neoplasms/radiotherapy* ; Abdominal Neoplasms/secondary ; Abdominal Neoplasms/surgery ; Computer Simulation ; Dose-Response Relationship, Radiation ; Female ; Genital Neoplasms, Female/pathology ; Genital Neoplasms, Female/radiotherapy* ; Genital Neoplasms, Female/surgery ; Humans ; Imaging, Three-Dimensional ; Pelvic Neoplasms/radiotherapy* ; Pelvic Neoplasms/secondary ; Pelvic Neoplasms/surgery ; Prognosis ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Conformal/methods* ; Radiotherapy, Intensity-Modulated/methods* ; Tomography, Spiral Computed/methods* ; Treatment Outcome
Keywords
Helical tomotherapy ; Whole abdominopelvic radiotherapy ; Gynecologic cancer ; Bone marrow
Abstract
OBJECTIVES: The goal of this study was to dosimetrically compare 3-dimensional radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), and helical tomotherapy (TOMO) plans for whole abdominopelvic radiotherapy (WART) in patients with gynecologic cancer. METHODS: Ten patients were selected for WART planning. Doses were prescribed to planning target volumes (PTVs) as the followings: 30 Gy to PTV-whole abdominopelvis (PTV-WA), 40 Gy to PTV-para-aortic lymph node (PTV-PALN), 44 Gy to PTV-pelvis, and 50 Gy to gross target volume (GTV) in 20 fractions. Dose to whole liver, both kidneys, and spinal cord were constrained below each tissue tolerance, and bone marrow (BM)-sparing technique was adopted in IMRT and TOMO. Dosimetric parameters and treatment times were compared among plans. RESULTS: Calculated doses in TOMO came most closely to the prescribed dose for coverage of PTV-WA, PTV-PALN, PTV-pelvis, and GTV compared to 3DCRT, and IMRT. In normal organs, TOMO had significantly better dosimetric profiles compared to IMRT and 3DCRT. TOMO significantly reduced V(20Gy), and mean dose of whole liver, both kidneys, and spinal cord. The use of BM-sparing technique (BMS) did not impair coverage of target volume in IMRT and TOMO. While IMRT showed no differences of irradiated BM dose using BMS, TOMO with BMS reduced half V(20Gy) of BM compared to TOMO without BMS. CONCLUSIONS: TOMO showed dosimetric superiority in target coverage, sparing BM, and other normal organs compared to 3DCRT and IMRT. Clinical experiences will be needed for evaluation of feasibility of WART using TOMO in patients with gynecologic cancer
Full Text
http://www.tcrt.org/Dosimetric-Comparisons-of-Three-dimensional-Conformal-Radiotherapy-Intensity-Modulated-Radiotherapy-and-Helical-Tomotherapy-in-Whole-Abdominopelvic-Radiotherapy-for-Gynecologic-Malignancy-369-378-p17742.html
DOI
10.1177/153303460900800507
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gwi Eon(김귀언)
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0001-7573-6862
Suh, Chang Ok(서창옥)
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Jeong, Kyoung Keun(정경근)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104385
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