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Oxidative status in iron-deficiency anemia.

Authors
 Jong-Ha Yoo  ;  Ho-Young Maeng  ;  Young-Kyu Sun  ;  Young-Ah Kim  ;  Dong-Wook Park  ;  Tae Sung Park  ;  Seung Tae Lee  ;  Jong-Rak Choi 
Citation
 JOURNAL OF CLINICAL LABORATORY ANALYSIS, Vol.23(5) : 319-323, 2009 
Journal Title
JOURNAL OF CLINICAL LABORATORY ANALYSIS
ISSN
 0887-8013 
Issue Date
2009
MeSH
Anemia, Iron-Deficiency/drug therapy ; Anemia, Iron-Deficiency/enzymology ; Anemia, Iron-Deficiency/metabolism* ; Antioxidants/metabolism ; Catalase/metabolism ; Female ; Ferrous Compounds/therapeutic use ; Hematinics/therapeutic use ; Humans ; Iron/metabolism ; Oxidants/metabolism ; Oxidation-Reduction ; Oxidative Stress*
Keywords
iron-deficiency anemia ; oxidative stress ; reactive oxygen species ; antioxidant ; catalase
Abstract
Oxidative stress is an imbalance between free radicals and antioxidant molecules that can play an important role in the pathogenesis of iron-deficiency anemia (IDA). The aim of this study was to investigate oxidative status in patients with IDA and alteration of oxidative status after iron treatment. Thirty-three female patients with IDA and 25 healthy controls were included in this study. Oxidant and total antioxidant capacity were determined using free oxygen radicals test and free oxygen radicals defence (Form CR 3000, Callegari, Parma, Italy). Catalase activity was measured by spectrophotometer using a commercially available kit (Bioxytech Catalase-520, OxisResearch, Portland, OR). Oxidant activity in patients with IDA was significantly higher than controls (P<0.05), while total antioxidant and catalase activity were significantly lower (P<0.05). After treatment, oxidant, antioxidant, and catalase activity reached the levels of the control group, and no significant differences were observed among groups (P>0.05). In conclusion, our data indicate that blood reactive oxygen species was lower and total antioxidant and catalase activity were higher after rather than before treatment in patients with IDA. The results of our study support the higher oxidative stress hypothesis in IDA; however, due to the limited number of cases included, more studies may be required to confirm the results
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jcla.20335/abstract
DOI
10.1002/jcla.20335
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Maeng, Ho Young(맹호영)
Park, Tae Sung(박태성)
Sun, Young Kyu(선영규)
Lee, Seung Tae(이승태)
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104358
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