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Restoration of bone turnover rate after decompression surgery in patients with symptomatic lumbar spinal stenosis: preliminary report.

 Ho-Joong Kim  ;  Hwan-Mo Lee  ;  Heoung-Jae Chun  ;  Kyoung-Tak Kang  ;  Hak-Sun Kim  ;  Jin-Oh Park  ;  Eun-Su Moon  ;  Kwang-Hwan Park  ;  Seong-Hwan Moon 
 SPINE, Vol.34(18) : 635-639, 2009 
Journal Title
Issue Date
Aged ; Alkaline Phosphatase/metabolism ; Bone Remodeling ; Bone and Bones/metabolism* ; Collagen Type I/metabolism ; Decompression, Surgical/methods* ; Female ; Follow-Up Studies ; Humans ; Lumbar Vertebrae/metabolism ; Lumbar Vertebrae/physiopathology ; Lumbar Vertebrae/surgery* ; Male ; Peptides/metabolism ; Prospective Studies ; Spinal Stenosis/metabolism ; Spinal Stenosis/physiopathology ; Spinal Stenosis/surgery* ; Time Factors ; Walking
lumbar spinal stenosis ; decompression surgery ; bone turnover rate ; bisphosphonates
STUDY DESIGN: Prospective short-term longitudinal study. OBJECTIVE: To investigate changes in the bone turnover rate in patients with lumbar spinal stenosis (LSS) before and after decompression surgery. SUMMARY OF BACK GROUND DATA: Decompression surgery enables elderly patients with LSS to participate in daily activities and physical exercise by reducing or alleviating leg and back pain. However, there have been no studies to date regarding the effect of decompression surgery on bone metabolism in such patients. METHODS: Twenty-three patients with spinal stenosis who were scheduled to undergo decompression surgery were enrolled in our study. Ten patients were given oral bisphosphonates after the operation (B+ group), while the remaining 13 patients did not receive oral bisphosphonate (B- group). In both groups, walking distance without rest, the Oswestry Disability Index (ODI) scores, duration of symptoms, bone formation, and resorption markers, and bone mineral density were recorded before surgery. Three months after surgery, bone turnover markers, a single trial for walking distance without rest and ODI scores were measured for both groups. RESULTS: Three months after the operation, the bone resorption marker u-NTx was decreased significantly for both groups. Although there was a decrease in bALP, a bone formation maker, in both groups, the change in each group was not statistical significant. Distance in a single trial walk was increased and ODI scores were decreased significantly for both groups. CONCLUSION: This study suggests that decompression surgery has a beneficial effect on bone metabolism in patients with LSS who have walking intolerance and limited physical activity.
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1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hak Sun(김학선) ORCID logo https://orcid.org/0000-0002-8330-4688
Kim, Ho Joong(김호중)
Moon, Seong Hwan(문성환)
Moon, Eun Su(문은수)
Park, Kwang Hwan(박광환) ORCID logo https://orcid.org/0000-0002-2110-0559
Park, Jin Oh(박진오)
Lee, Hwan Mo(이환모) ORCID logo https://orcid.org/0000-0002-5405-3832
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