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The role of MMP-9 in integrin-mediated hippocampal cell death after pilocarpine-induced status epilepticus

DC FieldValueLanguage
dc.contributor.author김경환-
dc.contributor.author김현우-
dc.contributor.author김현정-
dc.contributor.author이병인-
dc.contributor.author조경주-
dc.contributor.author조양제-
dc.date.accessioned2015-04-24T16:50:55Z-
dc.date.available2015-04-24T16:50:55Z-
dc.date.issued2009-
dc.identifier.issn0969-9961-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104287-
dc.description.abstractRecent studies demonstrate that matrix metalloproteinase-9 (MMP-9) is closely involved in the pathogenesis of epilepsy. This study investigated the role of MMP-9 in hippocampal cell death after pilocarpine-induced status epilepticus (SE). We showed that MMP-9 expression and activity significantly increased and beta1-integrin levels decreased on day 3 after SE. beta1-integrin degradation was also observed in hippocampal ex vivo extracts incubated with recombinant active MMP-9. Treatment with a selective MMP-9 inhibitor attenuated MMP-9 up-regulation, beta1-integrin degradation, the reduction of ILK activity and Akt phosphorylation, and subsequent hippocampal damage after SE. However, co-treatment with anti-beta1-integrin antibody almost completely blocked the protective effects of the MMP-9 inhibitor on both integrin-mediated survival signaling and hippocampal cell death. Our study demonstrates that MMP-9 induces apoptotic hippocampal cell death by interrupting integrin-mediated survival signaling after SE and suggests that MMP-9 may be a promising target for a neuroprotective approach to preventing seizure-induced hippocampal damage-
dc.description.statementOfResponsibilityopen-
dc.format.extent169~180-
dc.relation.isPartOfNeurobiology of Disease-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHAnimals-
dc.subject.MESHAntibodies/pharmacology-
dc.subject.MESHCaspase 3/metabolism-
dc.subject.MESHCell Death/drug effects-
dc.subject.MESHCell Death/physiology-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHEnzyme Inhibitors/pharmacology-
dc.subject.MESHHippocampus/drug effects-
dc.subject.MESHHippocampus/metabolism*-
dc.subject.MESHHippocampus/physiopathology*-
dc.subject.MESHIn Situ Nick-End Labeling/methods-
dc.subject.MESHIntegrin beta1/immunology-
dc.subject.MESHIntegrin beta1/metabolism*-
dc.subject.MESHMale-
dc.subject.MESHMatrix Metalloproteinase 2/metabolism-
dc.subject.MESHMatrix Metalloproteinase 9/metabolism*-
dc.subject.MESHMatrix Metalloproteinase Inhibitors-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHPhosphopyruvate Hydratase/metabolism-
dc.subject.MESHPropidium-
dc.subject.MESHSignal Transduction/drug effects-
dc.subject.MESHStatistics as Topic-
dc.subject.MESHStatus Epilepticus/chemically induced-
dc.subject.MESHStatus Epilepticus/drug therapy-
dc.subject.MESHStatus Epilepticus/pathology*-
dc.subject.MESHTime Factors-
dc.subject.MESHUp-Regulation/drug effects-
dc.titleThe role of MMP-9 in integrin-mediated hippocampal cell death after pilocarpine-induced status epilepticus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorGyung W. Kim-
dc.contributor.googleauthorHyun-Jeong Kim-
dc.contributor.googleauthorKyoung-Joo Cho-
dc.contributor.googleauthorHyun-Woo Kim-
dc.contributor.googleauthorYang-Je Cho-
dc.contributor.googleauthorByung I. Lee-
dc.identifier.doi10.1016/j.nbd.2009.07.008-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00310-
dc.contributor.localIdA02797-
dc.contributor.localIdA03804-
dc.contributor.localIdA03851-
dc.contributor.localIdA01130-
dc.contributor.localIdA01125-
dc.relation.journalcodeJ02323-
dc.identifier.pmid19631748-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S096999610900179X-
dc.subject.keywordMatrix metalloproteinase-
dc.subject.keywordIntegrins-
dc.subject.keywordPilocarpine-
dc.subject.keywordStatus epilepticus-
dc.contributor.alternativeNameKim, Gyung Whan-
dc.contributor.alternativeNameKim, Hyun Woo-
dc.contributor.alternativeNameKim, Hyun Jeong-
dc.contributor.alternativeNameLee, Byung In-
dc.contributor.alternativeNameCho, Kyuong Joo-
dc.contributor.alternativeNameCho, Yang Je-
dc.contributor.affiliatedAuthorKim, Gyung Whan-
dc.contributor.affiliatedAuthorLee, Byung In-
dc.contributor.affiliatedAuthorCho, Kyuong Joo-
dc.contributor.affiliatedAuthorCho, Yang Je-
dc.contributor.affiliatedAuthorKim, Hyun Jeong-
dc.contributor.affiliatedAuthorKim, Hyun Woo-
dc.citation.volume36-
dc.citation.number1-
dc.citation.startPage169-
dc.citation.endPage180-
dc.identifier.bibliographicCitationNeurobiology of Disease, Vol.36(1) : 169-180, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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