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Value of ventricular stiffness index and ventriculoarterial interaction in patients with nonischemic dilated cardiomyopathy

 Ae Young Her  ;  Jong-Youn Kim  ;  Eui-Young Choi  ;  Sung-Ai Kim  ;  Rhee Sang Jae  ;  Chi Young Shim  ;  Seok-Min Kang  ;  Jong-Won Ha  ;  Namsik Chung 
 CIRCULATION JOURNAL, Vol.73(9) : 1683-1690, 2009 
Journal Title
Issue Date
Adult ; Aged ; Arteries/diagnostic imaging ; Arteries/physiopathology ; Bicycling ; Cardiomyopathy, Dilated/diagnostic imaging ; Cardiomyopathy, Dilated/physiopathology* ; Case-Control Studies ; Echocardiography, Doppler* ; Elasticity ; Exercise Test ; Exercise Tolerance* ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology* ; Hemodynamics ; Humans ; Hypertension/diagnostic imaging ; Hypertension/physiopathology ; Male ; Middle Aged ; Myocardial Contraction* ; Observer Variation ; Physical Endurance ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Running ; Ventricular Function, Left*
Dilated cardiomyopathy ; Ventricular elastance ; Ventriculoarterial interaction
BACKGROUND: Whether echo-Doppler-derived index of ventricular elastance or ventriculoarterial interaction can reliably reflect circulatory efficiency in various conditions was investigated in the present study and whether they can be helpful in predicting exercise capacity in patients with dilated cardiomyopathy (DCM).

METHODS AND RESULTS: The 25 patients with DCM, 25 age- and gender-matched hypertensive patients, and 25 marathon runners underwent symptom-limited graded supine bicycle exercise echocardiography after resting echo-Doppler evaluation. Echo-Doppler-derived left ventricular (LV) diastolic elastance index (Ed), ventricular-vascular coupling index (10 x Ea/Ees), based on arterial elastance index (Ea) to LV end-systolic elastance index (Ees), and hemodynamic parameters were measured during rest and exercise. DCM patients had lower Ees, higher Ed and Ea/Ees with blunted exercise responses of Ees than the other groups, and the hypertensive patients had lower Ees and DeltaEes compared with the marathon runners. Resting Ed, Ea/Ees, and total stiffness index (10 x Ed x Ea/Ees) correlated with exercise duration independent of age and gender. A stiffness index of 0.8 could reliably predict impaired exercise capacity.

CONCLUSIONS: Echo-derived elastance is predictive of exercise capacity in patients with DCM
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Sung Ai(김성애)
Kim, Jong Youn(김종윤) ORCID logo https://orcid.org/0000-0001-7040-8771
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Chung, Nam Sik(정남식)
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
Her, Ae Young(허애영)
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