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The effect of intracoronary nicorandil on coronary myocardial bridging

Authors
 Jae-Hun Jung  ;  Pil-Ki Min  ;  Chong Won Sung  ;  Sang-Hak Lee  ;  Seonghoon Choi  ;  Jung Rae Cho  ;  Namho Lee  ;  Kyoung-Ha Park  ;  Min-Kyu Kim  ;  Woo Jung Park  ;  Yangsoo Jang 
Citation
 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, Vol.14(3) : 180-184, 2009 
Journal Title
 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS 
ISSN
 1074-2484 
Issue Date
2009
MeSH
Coronary Angiography ; Coronary Vessels/drug effects* ; Coronary Vessels/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Myocardial Bridging/diagnostic imaging ; Myocardial Bridging/drug therapy* ; Myocardial Bridging/physiopathology ; Nicorandil/administration & dosage* ; Prospective Studies ; Treatment Outcome ; Vasodilation/drug effects* ; Vasodilator Agents/administration & dosage*
Keywords
angina pectoris ; myocardial bridging ; nicorandil
Abstract
Medical treatments of coronary myocardial bridging (CMB) generally include beta-blockers and calcium channel blockers. Nitrates are avoided because symptoms may worsen. Nicorandil is a hybrid of a nitrate and a potassium channel opener. However, the effect of nicorandil on CMB is unknown. We analyzed nicorandil reactivity at the site with CMB in 51 patients. Maximal and minimal diameters of CMB were measured by quantitative angiography at baseline and at 60 seconds after intracoronary administration of 200 mg nicorandil. The maximal diameter during diastole increased from 2.15 + 0.42 mm to 2.34 + 0.44 mm after administration of nicorandil (P < .001), and the minimal diameter during systole increased from 1.24 + 0.63 mm to 1.67 + 0.64 mm (P < .001). Thus, nicorandil reduced the percentage vessel narrowing from 44.0 + 26.1% to 30.3 + 21.2% (P < .001). In 22 patients, we also evaluated the effect of nitroglycerin. The maximal diameter during diastole increased from 2.25 + 0.47 mm to 2.51 + 0.44 mm after administration of nitroglycerin (P < .019), and the minimal diameter during systole decreased from 1.28 + 0.64 mm to 1.14 + 0.60 mm (P = .276). Thus, nitroglycerin augmented the percentage vessel narrowing from 44.9% + 25.0% to 56.0% + 23.5% (P = .023). These results indicate that intracoronary administration of nicorandil could dilate coronary arteries during diastole as well as systole in patients with CMB during coronary angiography.
Full Text
http://cpt.sagepub.com/content/14/3/180
DOI
10.1177/1074248409338930
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Min, Pil Ki(민필기) ORCID logo https://orcid.org/0000-0001-7033-7651
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104218
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