2 525

Cited 43 times in

Drug-eluting stent in malignant biliary obstruction.

Authors
 Dong Ki Lee 
Citation
 JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Vol.16(5) : 628-632, 2009 
Journal Title
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
ISSN
 1868-6974 
Issue Date
2009
MeSH
Antineoplastic Agents/therapeutic use ; Bile Duct Neoplasms/complications ; Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/therapy* ; Catheterization/instrumentation ; Cholestasis/etiology ; Cholestasis/pathology* ; Cholestasis/therapy* ; Drug-Eluting Stents* ; Endoscopy, Digestive System/methods ; Female ; Humans ; Male ; Prognosis ; Risk Assessment ; Treatment Outcome
Keywords
Drug-eluting stent ; Malignant biliary obstruction ; Cholangiocarcinoma
Abstract
INTRODUCTION: In unresectable malignant bile duct obstruction, endoscopic stent insertion is the treatment of choice. However, the current stent allows only mechanical palliation of the obstruction, and has no anti-tumor effect. Currently, in the vascular field, the drug-eluting stent (DES) is very highly favored.

MATERIAL AND METHODS: The requirements for a DES in a non-vascular tract, such as the bile duct, are far different from those of a DES to be used in the vascular tract. The non-vascular DES must suppress tumor proliferation as well as mucosal hyperplasia. For example, the non-vascular stent might be covered with a membrane that gradually releases a chemo-agent. We do not have much experience with DES in the bile duct. Nonetheless, we are continuously testing many anti-tumor agents in animal and human studies.

CONCLUSION: We expect and hope DES will work effectively for tumor cells in diverse ways and, more importantly, will prolong stent patency and the patients' survival periods. But considerable investigation and a clinical study of DES will be required to achieve these goals.
Full Text
http://link.springer.com/article/10.1007%2Fs00534-009-0135-1
DOI
10.1007/s00534-009-0135-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Dong Ki(이동기) ORCID logo https://orcid.org/0000-0002-0048-9112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104167
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links