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Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats.

Authors
 Hyun Joo Lee  ;  Yong-ho Lee  ;  Sang Kyu Park  ;  Eun Seok Kang  ;  Hyo-Jeong Kim  ;  Young Chul Lee  ;  Cheol Soo Choi  ;  Se Eun Park  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Kwan Woo Lee  ;  Kyung-Sup Kim  ;  Sung Kil Lim  ;  Hyun Chul Lee 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.58(8) : 1170-1177, 2009 
Journal Title
 METABOLISM-CLINICAL AND EXPERIMENTAL 
ISSN
 0026-0495 
Issue Date
2009
MeSH
Animals ; Blotting, Western ; Diabetes Mellitus, Type 2/prevention & control* ; Glucose Tolerance Test ; Glucose Transporter Type 4/drug effects ; Glucose Transporter Type 4/metabolism ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/pharmacology* ; Insulin/metabolism* ; Insulin Resistance* ; Intra-Abdominal Fat/drug effects* ; Male ; Obesity/complications ; Obesity/metabolism* ; Obesity/physiopathology ; Panax* ; Plant Preparations/administration & dosage ; Plant Preparations/pharmacology* ; Rats ; Rats, Inbred OLETF
Abstract
Ginseng has been reported to ameliorate hyperglycemia in experimental and clinical studies; however, its mechanism of action remains unclear. In this study, we investigated the metabolic effects and putative molecular mechanisms of Korean red ginseng (KRG, Panax ginseng) in animal models for type 2 diabetes mellitus (T2DM) and peripheral insulin-responsive cell lines. Korean red ginseng was administered orally at a dose of 200 mg/(kg d) to Otsuka Long-Evans Tokushima fatty rats for 40 weeks. Initially, chronic administration of KRG reduced weight gain and visceral fat mass in the early period without altering food intake. The KRG-treated Otsuka Long-Evans Tokushima fatty rats showed improved insulin sensitivity and significantly preserved glucose tolerance compared with untreated control animals up to 50 weeks of age, implying that KRG attenuated the development of overt diabetes. KRG promoted fatty acid oxidation by the activation of adenosine monophosphate-activated protein kinase (AMPK) and phosphorylation of acetyl-coenzyme A carboxylase in skeletal muscle and cultured C2C12 muscle cells. Increased expression of peroxisome proliferator-activated receptor-gamma coactivator-1alpha, nuclear respiratory factor-1, cytochrome c, cytochrome c oxidase-4, and glucose transporter 4 by KRG treatment indicates that activated AMPK also enhanced mitochondrial biogenesis and glucose utilization in skeletal muscle. Although these findings suggest that KRG is likely to have beneficial effects on the amelioration of insulin resistance and the prevention of T2DM through the activation of AMPK, further clinical studies are required to evaluate the use of KRG as a supplementary agent for T2DM
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049509001255
DOI
10.1016/j.metabol.2009.03.015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Sup(김경섭) ORCID logo https://orcid.org/0000-0001-8483-8537
Park, Sang Kyu(박상규)
Park, Se Eun(박세은)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Lee, Hyun Joo(이현주)
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104145
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