224 273

Cited 0 times in

소아 불응성 만성 특발성 혈소판감소성자반증 환자에서의 Cyclosporine A의 치료 효과

Other Titles
 Role of Cyclosporine A in Pediatric Patients with Refractory Chronic Idiopathic Thrombocytopenic Purpura 
Authors
 김민정  ;  김효선  ;  권승연  ;  원성철  ;  김범식  ;  최성렬  ;  유철주 
Citation
 Clinical Pediatric Hematology-Oncology (임상소아혈액종양), Vol.16(1) : 1-8, 2009 
Journal Title
 Clinical Pediatric Hematology-Oncology (임상소아혈액종양) 
ISSN
 1225-6978 
Issue Date
2009
Keywords
Pediatric ; Chronic ; Thrombocytopenia ; Cyclosporine A
Abstract
Purpose: Since the treatment of chronic idiopathic thrombocytopenic purpura (ITP) remains unsatisfactory in patients refractory to standard therapy, alternative therapies such as splenectomy, danazol, rituximab and cyclosporine A (CsA) are being considered as recently. The efficacy and safety of CsA has already been proved to adult patients with chronic ITP, however, there was no previous study in pediatric patients. The purpose of this study was to evaluate the efficacy and side effect of CsA in pediatric chronic ITP patients. Methods: We reviewed medical records of nine steroid refractory chronic ITP patients diagnosed as chronic ITP who were treated with CsA during 2007 and 2009 retrospectively. Results: All nine patients received standard treatment of intravenous immunoglobulin G and steroid before receiving CsA. Average time duration to start CsA from diagnosis was 52 months. Three children (33%) showed more than partial response maintaining platelet count over 50×109/L, the other six patients did not show any effect. There were no remarkable toxicities other than mild chest discomfort and headache in two patients. Conclusion: CsA therapy is considered as a safe and effective treatment option in adult chronic ITP patients recently, however, there is nearly no study in pediatric patients only with few case reports. In this study only small portion of patients showed response to CsA. Since it was a small sized study with short term follow up, long term follow up with larger patient number is required to make conclusion
Files in This Item:
T200902259.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Seung Yeon(권승연)
Kim, Hyo Sun(김효선)
Won, Sung Chul(원성철)
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104107
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse