146 244

Cited 18 times in

Enzymatic properties of the N- and C-terminal halves of human hexokinase II.

DC FieldValueLanguage
dc.contributor.author김종선-
dc.contributor.author박전한-
dc.contributor.author안근재-
dc.contributor.author윤미진-
dc.contributor.author이종두-
dc.date.accessioned2015-04-24T16:43:41Z-
dc.date.available2015-04-24T16:43:41Z-
dc.date.issued2009-
dc.identifier.issn1976-6696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104059-
dc.description.abstractAlthough previous studies on hexokinase (HK) II indicate both the N- and C-terminal halves are catalytically active, we show in this study the N-terminal half is significantly more catalytic than the C-terminal half in addition to having a significantly higher Km for ATP and Glu. Furthermore, truncated forms of intact HK II lacking its first N-terminal 18 amino acids (delta18) and a truncated N-terminal half lacking its first 18 amino acids (delta18N) have higher catalytic activity than other mutants tested. Similar results were obtained by PET-scan analysis using (18)FFDG. Our results collectively suggest that each domain of HK II possesses enzyme activity, unlike HK I, with the N-terminal half showing higher enzyme activity than the C-terminal half-
dc.description.statementOfResponsibilityopen-
dc.format.extent350~355-
dc.relation.isPartOfBMB Reports-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEnzymatic properties of the N- and C-terminal halves of human hexokinase II.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학)-
dc.contributor.googleauthorKeun Jae Ahn-
dc.contributor.googleauthorJongsun Kim-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorJeon Han Park-
dc.contributor.googleauthorJong Doo Lee-
dc.identifier.doi10.5483/BMBRep.2009.42.6.350-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00921-
dc.contributor.localIdA01641-
dc.contributor.localIdA02222-
dc.contributor.localIdA02550-
dc.contributor.localIdA03138-
dc.relation.journalcodeJ00348-
dc.contributor.alternativeNameKim, Jong Sun-
dc.contributor.alternativeNamePark, Jeon Han-
dc.contributor.alternativeNameAhn, Keun Jae-
dc.contributor.alternativeNameYun, Mi Jin-
dc.contributor.alternativeNameLee, Jong Doo-
dc.contributor.affiliatedAuthorKim, Jong Sun-
dc.contributor.affiliatedAuthorPark, Jeon Han-
dc.contributor.affiliatedAuthorAhn, Keun Jae-
dc.contributor.affiliatedAuthorYun, Mi Jin-
dc.contributor.affiliatedAuthorLee, Jong Doo-
dc.citation.volume42-
dc.citation.number6-
dc.citation.startPage350-
dc.citation.endPage355-
dc.identifier.bibliographicCitationBMB Reports, Vol.42(6) : 350-355, 2009-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.