Cited 9 times in
Post-ischemic administration of peptide with apurinic/apyrimidinic endonuclease activity inhibits induction of cell death after focal cerebral ischemia/reperfusion in mice
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.contributor.author | 김현우 | - |
dc.contributor.author | 김현정 | - |
dc.contributor.author | 이병인 | - |
dc.contributor.author | 조경주 | - |
dc.date.accessioned | 2015-04-24T16:43:39Z | - |
dc.date.available | 2015-04-24T16:43:39Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104058 | - |
dc.description.abstract | Previous scientific research has elucidated the correlation between changes in levels of the DNA base excision repair protein, apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1), and ischemic neuronal DNA damage. However, to date, no studies have addressed the question of whether treatment involving this protein's repair function may prevent ischemic neuron death in vivo. Therefore, we aimed to investigate whether treatment with APE peptide is sufficient to prevent neuron death after ischemia/reperfusion (I/R) in mice. Mice were subjected to intraluminal suture occlusion of the middle cerebral artery for 1h followed by reperfusion. Post-ischemic treatment with the peptide containing only the APE repair functional domain was introduced intracerebroventricularly. Endonuclease activity assay and immunohistochemistry were performed. Assays of apurinic/apyrimidinic (AP) sites, single-strand DNA breaks, caspase-3 activity, and cell death were examined and quantified. We found that post-ischemic administration of the APE peptide up to 4h after reperfusion significantly inhibited the induction of cell death and subsequent infarct volume, measured 24h after I/R. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 166~169 | - |
dc.relation.isPartOf | NEUROSCIENCE LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Brain Ischemia/drug therapy | - |
dc.subject.MESH | Brain Ischemia/enzymology | - |
dc.subject.MESH | Brain Ischemia/pathology* | - |
dc.subject.MESH | Caspase 3/metabolism | - |
dc.subject.MESH | Cell Death/drug effects | - |
dc.subject.MESH | DNA Breaks, Single-Stranded | - |
dc.subject.MESH | DNA-(Apurinic or Apyrimidinic Site) Lyase/administration & dosage | - |
dc.subject.MESH | DNA-(Apurinic or Apyrimidinic Site) Lyase/pharmacology* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Endodeoxyribonucleases/metabolism | - |
dc.subject.MESH | Endoribonucleases/metabolism | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay/methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Peptides/administration & dosage | - |
dc.subject.MESH | Peptides/pharmacology* | - |
dc.subject.MESH | Reperfusion Injury/drug therapy | - |
dc.subject.MESH | Reperfusion Injury/enzymology | - |
dc.subject.MESH | Reperfusion Injury/pathology* | - |
dc.subject.MESH | Tetrazolium Salts | - |
dc.subject.MESH | Time Factors | - |
dc.title | Post-ischemic administration of peptide with apurinic/apyrimidinic endonuclease activity inhibits induction of cell death after focal cerebral ischemia/reperfusion in mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Hyun-Woo Kim | - |
dc.contributor.googleauthor | Kyoung-Joo Cho | - |
dc.contributor.googleauthor | Byung I. Lee | - |
dc.contributor.googleauthor | Hyun-jeong Kim | - |
dc.contributor.googleauthor | GyungW. Kim | - |
dc.identifier.doi | 10.1016/j.neulet.2009.05.062 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00310 | - |
dc.contributor.localId | A02797 | - |
dc.contributor.localId | A03804 | - |
dc.contributor.localId | A01130 | - |
dc.contributor.localId | A01125 | - |
dc.relation.journalcode | J02364 | - |
dc.identifier.eissn | 1872-7972 | - |
dc.identifier.pmid | 19481583 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304394009007113 | - |
dc.subject.keyword | Transient focal cerebral ischemia | - |
dc.subject.keyword | DNA repair | - |
dc.subject.keyword | Stroke | - |
dc.subject.keyword | Apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) | - |
dc.contributor.alternativeName | Kim, Gyung Whan | - |
dc.contributor.alternativeName | Kim, Hyun Woo | - |
dc.contributor.alternativeName | Kim, Hyun Jeong | - |
dc.contributor.alternativeName | Lee, Byung In | - |
dc.contributor.alternativeName | Cho, Kyuong Joo | - |
dc.contributor.affiliatedAuthor | Kim, Gyung Whan | - |
dc.contributor.affiliatedAuthor | Lee, Byung In | - |
dc.contributor.affiliatedAuthor | Cho, Kyuong Joo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Woo | - |
dc.citation.volume | 460 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 166 | - |
dc.citation.endPage | 169 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, Vol.460(2) : 166-169, 2009 | - |
dc.identifier.rimsid | 46796 | - |
dc.type.rims | ART | - |
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