Cited 16 times in
The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현정 | - |
dc.contributor.author | 박수철 | - |
dc.contributor.author | 조경주 | - |
dc.contributor.author | 김경환 | - |
dc.contributor.author | 김현우 | - |
dc.date.accessioned | 2015-04-24T16:43:33Z | - |
dc.date.available | 2015-04-24T16:43:33Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104055 | - |
dc.description.abstract | Despite the correlation between changes in the levels of apurinic/apyrimidinic endonuclease and ischemic neuronal damage, no studies have addressed the question of whether increased APE/Ref-1 can prevent ischemic neuronal cell death in vivo. Using an adenoviral vector, we investigated whether increased APE/Ref-1 can inhibit the loss of APE/Ref-1 and thereby prevent oxidative DNA damage after transient focal cerebral ischemia. Mice were subjected to intraluminal suture occlusion of the middle cerebral artery for 1 h, followed by reperfusion. Pre-ischemic treatment of the adenoviral vector was introduced intracerebrally. An adenoviral vector harboring the entire APE/Ref-1 gene sequence or a control virus without the APE/Ref-1 sequence was introduced 3 days before ischemia/reperfusion (I/R). The reduction of APE/Ref-1 occurred before DNA fragmentation, which was shown by temporal and spatial analysis. Increased APE/Ref-1 significantly decreased DNA damage and infarct volume after I/R. In conclusion, increased APE/Ref-1 enhanced DNA repair and inhibited the induction of ischemic oxidative DNA damage and cerebral infarction after I/R | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~10 | - |
dc.relation.isPartOf | BRAIN RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenoviridae/genetics | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Death/genetics | - |
dc.subject.MESH | Cerebrovascular Circulation/physiology | - |
dc.subject.MESH | DNA Fragmentation* | - |
dc.subject.MESH | DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics* | - |
dc.subject.MESH | DNA-(Apurinic or Apyrimidinic Site) Lyase/metabolism | - |
dc.subject.MESH | Fluorescent Antibody Technique | - |
dc.subject.MESH | Free Radicals/metabolism | - |
dc.subject.MESH | Genetic Therapy/methods* | - |
dc.subject.MESH | Genetic Vectors | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Infarction, Middle Cerebral Artery/complications | - |
dc.subject.MESH | Ischemic Attack, Transient/etiology | - |
dc.subject.MESH | Ischemic Attack, Transient/genetics* | - |
dc.subject.MESH | Ischemic Attack, Transient/pathology | - |
dc.subject.MESH | Laser-Doppler Flowmetry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Neurons/pathology* | - |
dc.subject.MESH | Oxidative Stress/physiology | - |
dc.subject.MESH | Reperfusion Injury/etiology | - |
dc.subject.MESH | Reperfusion Injury/genetics* | - |
dc.subject.MESH | Reperfusion Injury/pathology | - |
dc.title | The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Hyun-Woo Kim | - |
dc.contributor.googleauthor | Kyoung-Joo Cho | - |
dc.contributor.googleauthor | Soo-Chul Park | - |
dc.contributor.googleauthor | Hyun-Jeong Kim | - |
dc.contributor.googleauthor | Gyung W. Kim | - |
dc.identifier.doi | 10.1016/j.brainres.2009.04.006 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01543 | - |
dc.contributor.localId | A03804 | - |
dc.contributor.localId | A00310 | - |
dc.contributor.localId | A01125 | - |
dc.contributor.localId | A01130 | - |
dc.relation.journalcode | J00392 | - |
dc.identifier.eissn | 1872-6240 | - |
dc.identifier.pmid | 19374886 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006899309007355 | - |
dc.subject.keyword | DNA repair | - |
dc.subject.keyword | DNA fragmentation | - |
dc.subject.keyword | Cerebral ischemia | - |
dc.subject.keyword | Adenoviral vector | - |
dc.contributor.alternativeName | Kim, Hyun Jeong | - |
dc.contributor.alternativeName | Park, Soo Chul | - |
dc.contributor.alternativeName | Cho, Kyuong Joo | - |
dc.contributor.alternativeName | Kim, Gyung Whan | - |
dc.contributor.alternativeName | Kim, Hyun Woo | - |
dc.contributor.affiliatedAuthor | Park, Soo Chul | - |
dc.contributor.affiliatedAuthor | Cho, Kyuong Joo | - |
dc.contributor.affiliatedAuthor | Kim, Gyung Whan | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Woo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Jeong | - |
dc.citation.volume | 1274 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.identifier.bibliographicCitation | BRAIN RESEARCH, Vol.1274 : 1-10, 2009 | - |
dc.identifier.rimsid | 46795 | - |
dc.type.rims | ART | - |
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