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The relationship between antifungal usage and antifungal susceptibility in clinical isolates of Candida: a multicenter Korean study

Authors
 SOO HYUN KIM  ;  JONG HEE SHIN  ;  EUI-CHONG KIM  ;  KYUNGWON LEE  ;  MI-NA KIM  ;  WON GIL LEE  ;  YOUNG UH  ;  HYE SOO LEE  ;  MI-KYUNG LEE  ;  SEOK HOON JEONG  ;  SOOK IN JUNG  ;  KYUNG HWA PARK  ;  JIN-SOL LEE  ;  MYUNG GEUN SHIN  ;  SOON PAL SUH  ;  DONG WOOK RYANG 
Citation
 MEDICAL MYCOLOGY, Vol.47(3) : 296-304, 2009 
Journal Title
 MEDICAL MYCOLOGY 
ISSN
 1369-3786 
Issue Date
2009
MeSH
Amphotericin B/pharmacology ; Antifungal Agents/pharmacology* ; Candida/drug effects* ; Candida/isolation & purification ; Candidiasis/drug therapy* ; Candidiasis/microbiology* ; Drug Resistance, Fungal* ; Drug Utilization/statistics & numerical data* ; Fluconazole/pharmacology ; Hospitals ; Humans ; Itraconazole/pharmacology ; Korea ; Microbial Sensitivity Tests
Keywords
Candida spp. ; antifungal susceptibility ; antifungals ; DDD ; fluconazole
Abstract
There have been very few multicenter studies of the relationship between the use of antifungals and resistance to them. We investigated the antifungal susceptibility of 1,301 clinical isolates of Candida collected from nine Korean hospitals during a 3-month period in 2006 to explore the existence of this type of relationship. Antifungal usage in the preceding year, defined as the daily dose per 1,000 patient days (DDD/1,000 PD), was calculated for each hospital. Resistance to fluconazole, itraconazole, and amphotericin B was detected in 2, 9, and 0.2% of the isolates, respectively. The MIC(50)/MIC(90) values were 0.03/0.125 mg/L for voriconazole, 0.06/0.25 mg/l for caspofungin, and 0.03/0.125 mg/l for micafungin. The total usage of systemic antifungals varied considerably among the nine hospitals, ranging from 6.1 to 96.2 DDD/1,000 PD. No relationship was found between the use of fluconazole (MIC> or =64 mg/l) or itraconazole (MIC> or =1 mg/l) and resistance in the Candida species (P>0.05). However, significant correlations were found between the percentage of Candida isolates that were non-susceptible to fluconazole (MIC> or =16 mg/l) and fluconazole usage (r=0.733, P=0.025) or total antifungal usage (r=0.767, P=0.016).
Full Text
http://informahealthcare.com/doi/abs/10.1080/13693780802291445
DOI
10.1080/13693780802291445
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/104044
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