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Cited 26 times in

The forkhead transcription factor Foxc2 stimulates osteoblast differentiation

DC FieldValueLanguage
dc.contributor.author박수진-
dc.contributor.author이유미-
dc.contributor.author임승길-
dc.contributor.author정한성-
dc.contributor.author조경원-
dc.contributor.author최한석-
dc.date.accessioned2015-04-24T16:43:02Z-
dc.date.available2015-04-24T16:43:02Z-
dc.date.issued2009-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104039-
dc.description.abstractThe forkhead box C2 (Foxc2) protein is a member of the family of winged helix/forkhead transcription factors. Foxc2-deficient mice display defective formation of the aortic arches, multiple craniofacial bones, and vertebral columns. To investigate the role of Foxc2 in osteoblast differentiation, DNA containing Foxc2 was transfected into the developing cranial suture mesenchymal cells by electroporation. Compared to the controls, alkaline phosphatase (ALP) and bone sialoprotein were expressed strongly in suture mesenchymal cells in the Foxc2 overexpressed calvaria. After Foxc2-siRNA transfection, ALP staining was rarely observed in the suture mesenchyme and adjacent parietal bone of the calvaria. Meanwhile, overexpression of Foxc2 increased protein levels of beta-catenin and stimulated TCF/LEF transcriptional activity. The protein kinase A inhibitor H-89 suppressed Foxc2-mediated increases in TCF/LEF transcriptional activity (-40%, P<0.01). In conclusion, our results demonstrated that Foxc2 stimulated osteoblast differentiation of mesenchymal cells and preosteoblasts. Activation of canonical Wnt-beta-catenin signals might be involved in the Foxc2-mediated stimulation of osteoblast differentiation-
dc.description.statementOfResponsibilityopen-
dc.format.extent532~536-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Differentiation*-
dc.subject.MESHCell Line-
dc.subject.MESHForkhead Transcription Factors/genetics-
dc.subject.MESHForkhead Transcription Factors/physiology*-
dc.subject.MESHMesenchymal Stromal Cells/cytology*-
dc.subject.MESHMesenchymal Stromal Cells/metabolism-
dc.subject.MESHMice-
dc.subject.MESHOrgan Culture Techniques-
dc.subject.MESHOsteoblasts/cytology-
dc.subject.MESHOsteoblasts/physiology*-
dc.subject.MESHRNA, Small Interfering/genetics-
dc.subject.MESHSkull/cytology-
dc.subject.MESHWnt Proteins/metabolism-
dc.subject.MESHbeta Catenin/metabolism-
dc.titleThe forkhead transcription factor Foxc2 stimulates osteoblast differentiation-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorSe Hwa Kim-
dc.contributor.googleauthorKyoung-Won Cho-
dc.contributor.googleauthorHan Seok Choi-
dc.contributor.googleauthorSu Jin Park-
dc.contributor.googleauthorYumie Rhee-
dc.contributor.googleauthorHan-Sung Jung-
dc.contributor.googleauthorSAung-Kil Lim-
dc.identifier.doi10.1016/j.bbrc.2009.06.071-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03012-
dc.contributor.localIdA03375-
dc.contributor.localIdA03758-
dc.contributor.localIdA03802-
dc.contributor.localIdA04206-
dc.contributor.localIdA01540-
dc.relation.journalcodeJ00281-
dc.identifier.eissn1090-2104-
dc.identifier.pmid19540201-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006291X09012236-
dc.subject.keywordFoxc2-
dc.subject.keywordWnt-
dc.subject.keywordβ-catenin-
dc.subject.keywordOsteoblast-
dc.subject.keywordTCF/LEF-
dc.subject.keywordOsteoblast differentiation-
dc.contributor.alternativeNamePark, Su Jin-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.alternativeNameCho, Kyoung Won-
dc.contributor.alternativeNameChoi, Han Seok-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.contributor.affiliatedAuthorCho, Kyoung Won-
dc.contributor.affiliatedAuthorChoi, Han Seok-
dc.contributor.affiliatedAuthorPark, Su Jin-
dc.citation.volume386-
dc.citation.number3-
dc.citation.startPage532-
dc.citation.endPage536-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.386(3) : 532-536, 2009-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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