Cited 36 times in
The forkhead transcription factor Foxc2 stimulates osteoblast differentiation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박수진 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 정한성 | - |
dc.contributor.author | 조경원 | - |
dc.contributor.author | 최한석 | - |
dc.date.accessioned | 2015-04-24T16:43:02Z | - |
dc.date.available | 2015-04-24T16:43:02Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104039 | - |
dc.description.abstract | The forkhead box C2 (Foxc2) protein is a member of the family of winged helix/forkhead transcription factors. Foxc2-deficient mice display defective formation of the aortic arches, multiple craniofacial bones, and vertebral columns. To investigate the role of Foxc2 in osteoblast differentiation, DNA containing Foxc2 was transfected into the developing cranial suture mesenchymal cells by electroporation. Compared to the controls, alkaline phosphatase (ALP) and bone sialoprotein were expressed strongly in suture mesenchymal cells in the Foxc2 overexpressed calvaria. After Foxc2-siRNA transfection, ALP staining was rarely observed in the suture mesenchyme and adjacent parietal bone of the calvaria. Meanwhile, overexpression of Foxc2 increased protein levels of beta-catenin and stimulated TCF/LEF transcriptional activity. The protein kinase A inhibitor H-89 suppressed Foxc2-mediated increases in TCF/LEF transcriptional activity (-40%, P<0.01). In conclusion, our results demonstrated that Foxc2 stimulated osteoblast differentiation of mesenchymal cells and preosteoblasts. Activation of canonical Wnt-beta-catenin signals might be involved in the Foxc2-mediated stimulation of osteoblast differentiation | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 532~536 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Differentiation* | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Forkhead Transcription Factors/genetics | - |
dc.subject.MESH | Forkhead Transcription Factors/physiology* | - |
dc.subject.MESH | Mesenchymal Stromal Cells/cytology* | - |
dc.subject.MESH | Mesenchymal Stromal Cells/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Organ Culture Techniques | - |
dc.subject.MESH | Osteoblasts/cytology | - |
dc.subject.MESH | Osteoblasts/physiology* | - |
dc.subject.MESH | RNA, Small Interfering/genetics | - |
dc.subject.MESH | Skull/cytology | - |
dc.subject.MESH | Wnt Proteins/metabolism | - |
dc.subject.MESH | beta Catenin/metabolism | - |
dc.title | The forkhead transcription factor Foxc2 stimulates osteoblast differentiation | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Se Hwa Kim | - |
dc.contributor.googleauthor | Kyoung-Won Cho | - |
dc.contributor.googleauthor | Han Seok Choi | - |
dc.contributor.googleauthor | Su Jin Park | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Han-Sung Jung | - |
dc.contributor.googleauthor | SAung-Kil Lim | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.06.071 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A03758 | - |
dc.contributor.localId | A03802 | - |
dc.contributor.localId | A04206 | - |
dc.contributor.localId | A01540 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 19540201 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X09012236 | - |
dc.subject.keyword | Foxc2 | - |
dc.subject.keyword | Wnt | - |
dc.subject.keyword | β-catenin | - |
dc.subject.keyword | Osteoblast | - |
dc.subject.keyword | TCF/LEF | - |
dc.subject.keyword | Osteoblast differentiation | - |
dc.contributor.alternativeName | Park, Su Jin | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.alternativeName | Cho, Kyoung Won | - |
dc.contributor.alternativeName | Choi, Han Seok | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Cho, Kyoung Won | - |
dc.contributor.affiliatedAuthor | Choi, Han Seok | - |
dc.contributor.affiliatedAuthor | Park, Su Jin | - |
dc.citation.volume | 386 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 532 | - |
dc.citation.endPage | 536 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.386(3) : 532-536, 2009 | - |
dc.identifier.rimsid | 46785 | - |
dc.type.rims | ART | - |
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