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Inhibition of choroidal neovascularisation in mice by systemic administration of the multikinase inhibitor, sorafenib.

DC Field Value Language
dc.contributor.author고형준-
dc.contributor.author이준행-
dc.contributor.author정은지-
dc.date.accessioned2015-04-24T16:42:02Z-
dc.date.available2015-04-24T16:42:02Z-
dc.date.issued2009-
dc.identifier.issn0007-1161-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/104008-
dc.description.abstractBACKGROUND: To investigate the effect of orally administered sorafenib, a multikinase inhibitor, in a mouse model of choroidal neovascularisation (CNV). METHODS: Sorafenib or vehicle was administered orally to female C57BL/6 mice at the onset (day 0) of experiments. CNV was induced by laser photocoagulation the following day. After 14 days, mice were perfused with fluorescein-labelled dextran, and the area of CNV was measured on choroidal flat mounts by image analysis. In some groups of mice, treatments were started 7 days after the laser photocoagulation to determine the effect of the agent on established CNV. Expression of phosphorylated extracellular signal-regulated kinase (p-ERK) in choroidal tissues was measured by Western blot analysis to demonstrate the kinase-inhibitory effect of sorafenib in intracellular signalling pathways involved in CNV formation. RESULTS: Sorafenib significantly reduced the extent of CNV in a dose-dependent manner. The area of CNV was reduced by 43% in the 30 mg/kg/day group and by 61% in the 60 mg/kg/day group compared with vehicle-treated controls (both p<0.0001). Oral administration of sorafenib also caused significant regression of established CNV. The area of CNV was reduced by 59% in the 30 mg/kg/day group and by 66% in the 60 mg/kg/day group compared with both baseline and control measurements (p<0.0001). The expression of p-ERK in choroidal tissues was increased within 1 day of laser photocoagulation and remained elevated for 2 weeks. The expression of p-ERK was suppressed by sorafenib. CONCLUSIONS: Sorafenib demonstrated antiangiogenic properties in a mouse model of CNV and may be useful in the treatment of CNV-
dc.description.statementOfResponsibilityopen-
dc.format.extent958~963-
dc.relation.isPartOfBRITISH JOURNAL OF OPHTHALMOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHAngiogenesis Inhibitors/administration & dosage*-
dc.subject.MESHAnimals-
dc.subject.MESHBenzenesulfonates/administration & dosage*-
dc.subject.MESHBlotting, Western-
dc.subject.MESHChoroidal Neovascularization/drug therapy*-
dc.subject.MESHDextrans/administration & dosage-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHFemale-
dc.subject.MESHFluoresceins/administration & dosage-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHNiacinamide/analogs & derivatives-
dc.subject.MESHPhenylurea Compounds-
dc.subject.MESHPyridines/administration & dosage*-
dc.titleInhibition of choroidal neovascularisation in mice by systemic administration of the multikinase inhibitor, sorafenib.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorE J Chung-
dc.contributor.googleauthorS Yoo-
dc.contributor.googleauthorH J Lim-
dc.contributor.googleauthorS H Byeon-
dc.contributor.googleauthorJ H Lee-
dc.contributor.googleauthorH J Koh-
dc.identifier.doi10.1136/bjo.2008.149187-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00152-
dc.contributor.localIdA03180-
dc.contributor.localIdA03689-
dc.relation.journalcodeJ00412-
dc.identifier.eissn1468-2079-
dc.identifier.pmid19028740-
dc.identifier.urlhttp://bjo.bmj.com/content/93/7/958.long-
dc.contributor.alternativeNameKoh, Hyoung Jun-
dc.contributor.alternativeNameLee, Joon Haeng-
dc.contributor.alternativeNameChung, Eun Jee-
dc.contributor.affiliatedAuthorKoh, Hyoung Jun-
dc.contributor.affiliatedAuthorLee, Joon Haeng-
dc.contributor.affiliatedAuthorChung, Eun Jee-
dc.citation.volume93-
dc.citation.number7-
dc.citation.startPage958-
dc.citation.endPage963-
dc.identifier.bibliographicCitationBRITISH JOURNAL OF OPHTHALMOLOGY, Vol.93(7) : 958-963, 2009-
dc.identifier.rimsid46764-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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