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Botulinum toxin: a treatment for compensatory hyperhidrosis in the trunk

Authors
 WON OAK KIM  ;  HAE KEUM KIL  ;  KYUNG BONG YOON  ;  KO UN NOH 
Citation
 DERMATOLOGIC SURGERY, Vol.35(5) : 833-838, 2009 
Journal Title
 DERMATOLOGIC SURGERY 
ISSN
 1076-0512 
Issue Date
2009
MeSH
Adult ; Botulinum Toxins, Type A/administration & dosage* ; Female ; Follow-Up Studies ; Humans ; Hyperhidrosis/drug therapy* ; Injections ; Male ; Neurotoxins/administration & dosage* ; Retrospective Studies ; Thorax ; Time Factors ; Treatment Outcome
Abstract
BACKGROUND: Severe compensatory hyperhidrosis (CH) in the trunk occurs after sympathectomy in some patients. Limited treatment options for these cases have been proposed, and the overall results have been disappointing, but injection of botulinum toxin-A (BTX-A) is an emerging, reliable treatment method for focal hyperhidrosis. OBJECTIVE: To demonstrate the efficacy, longevity, and safety of BTX-A injection for severe truncal sweating in CH patients who were refractory to conventional treatment. METHODS: Seventeen patients were injected with 100 to 500 U of BTX-A in the truncal area. After the follow-up period, the Hyperhidrosis Disease Severity Scale (HDSS) for efficacy and the Dermatology Life Quality Index (DLQI) were measured for improvement in patients' quality of life. RESULTS: The baseline mean HDSS score+/-standard deviation was 3.6+/-0.5, and the sweating resolved within 5 days. The effect was sustained for 2 to 8 months (4.1+/-1.5 months) and the baseline DLQI score of 9.4+/-2.0 fell to 2.8+/-1.0. No serious side effects or adverse events resulted from the treatment. CONCLUSIONS: BTX-A injection was a well-tolerated, effective, and safe method for treating severe truncal CH, although the considerable cost and limited duration of the treatment effects were major disadvantages.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1524-4725.2009.01140.x/abstract
DOI
10.1111/j.1524-4725.2009.01140.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kil, Hae Keum(길혜금)
Kim, Won Oak(김원옥)
Yoon, Kyoung Bong(윤경봉) ORCID logo https://orcid.org/0000-0002-4167-1375
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/103958
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