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Regulator of G-protein signaling 4 suppresses LPS-induced MUC5AC overproduction in the airway

DC Field Value Language
dc.contributor.author김규보-
dc.contributor.author김현준-
dc.contributor.author송경섭-
dc.contributor.author윤주헌-
dc.contributor.author이정권-
dc.date.accessioned2015-04-24T16:39:24Z-
dc.date.available2015-04-24T16:39:24Z-
dc.date.issued2009-
dc.identifier.issn1044-1549-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/103924-
dc.description.abstractMucus overproduction and airway obstruction are common features in airway mucosal inflammation. The mechanism by which LPS induces MUC5AC overexpression, however, has not been fully explored. The aims of this study were twofold: first, to examine the ATP-dependent mechanism by which LPS induces MUC5AC gene expression, and second, to identify specific molecules that could suppress LPS-induced MUC5AC expression at a G-protein-coupled receptor level. Here, we suggest that LPS from Pseudomonas aeruginosa induces MUC5AC overproduction by both an ATP-dependent pathway and an ATP-independent pathway. In addition, we showed that Regulator of G-protein signaling (RGS) 4 plays as a suppressor for ATP-induced MUC5AC expression by interacting with G alpha q in a GTP-dependent manner in vivo. These results give additional insights into the molecular mechanism of negative regulation of mucin overproduction and enhance our understanding of mucus hypersecretion during airway mucosal inflammation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent40~49-
dc.relation.isPartOfAMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenosine Triphosphate/metabolism-
dc.subject.MESHAnimals-
dc.subject.MESHCells, Cultured-
dc.subject.MESHEpithelial Cells/drug effects*-
dc.subject.MESHEpithelial Cells/metabolism-
dc.subject.MESHEpithelial Cells/pathology-
dc.subject.MESHGTP-Binding Protein alpha Subunits, Gq-G11/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHLipopolysaccharides/isolation & purification-
dc.subject.MESHLipopolysaccharides/pharmacology*-
dc.subject.MESHMetaplasia-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMucin 5AC/genetics-
dc.subject.MESHMucin 5AC/metabolism*-
dc.subject.MESHNasal Mucosa/drug effects-
dc.subject.MESHNasal Mucosa/metabolism-
dc.subject.MESHPseudomonas aeruginosa/chemistry-
dc.subject.MESHRGS Proteins/deficiency-
dc.subject.MESHRGS Proteins/genetics-
dc.subject.MESHRGS Proteins/metabolism*-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHReceptors, Purinergic P2/drug effects-
dc.subject.MESHReceptors, Purinergic P2/metabolism-
dc.subject.MESHReceptors, Purinergic P2Y2-
dc.subject.MESHRespiratory Mucosa/drug effects*-
dc.subject.MESHRespiratory Mucosa/metabolism-
dc.subject.MESHRespiratory Mucosa/pathology-
dc.subject.MESHTime Factors-
dc.subject.MESHToll-Like Receptor 4/drug effects-
dc.subject.MESHToll-Like Receptor 4/metabolism-
dc.subject.MESHTransfection-
dc.subject.MESHUp-Regulation-
dc.titleRegulator of G-protein signaling 4 suppresses LPS-induced MUC5AC overproduction in the airway-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorKyoung Seob Song-
dc.contributor.googleauthorHyun Jun Kim-
dc.contributor.googleauthorKyubo Kim-
dc.contributor.googleauthorJeung Gweon Lee-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.identifier.doi10.1165/rcmb.2008-0280OC-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00323-
dc.contributor.localIdA01137-
dc.contributor.localIdA02604-
dc.contributor.localIdA03095-
dc.contributor.localIdA02010-
dc.relation.journalcodeJ00113-
dc.identifier.eissn1535-4989-
dc.identifier.pmid19059885-
dc.identifier.urlhttp://www.atsjournals.org/doi/abs/10.1165/rcmb.2008-0280OC?journalCode=ajrcmb-
dc.subject.keywordlipopolysaccharide-
dc.subject.keywordATP-
dc.subject.keywordMUC5AC-
dc.subject.keywordP2Y2-
dc.subject.keywordRGS4-
dc.contributor.alternativeNameKim, Kyu Bo-
dc.contributor.alternativeNameKim, Hyun Jun-
dc.contributor.alternativeNameSong, Kyoung Seob-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.alternativeNameLee, Jeung Gweon-
dc.contributor.affiliatedAuthorKim, Kyu Bo-
dc.contributor.affiliatedAuthorKim, Hyun Jun-
dc.contributor.affiliatedAuthorYoon, Joo Heon-
dc.contributor.affiliatedAuthorLee, Jeung Gweon-
dc.contributor.affiliatedAuthorSong, Kyoung Seob-
dc.citation.volume41-
dc.citation.number1-
dc.citation.startPage40-
dc.citation.endPage49-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol.41(1) : 40-49, 2009-
dc.identifier.rimsid37889-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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